Perspectives on Cyclobutane Pyrimidine Dimers-Rise of the Dark Dimers.
Perspectives on Cyclobutane Pyrimidine Dimers-Rise of the Dark Dimers.
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环丁烷嘧啶二聚体的观点——黑暗二聚体的兴起。
DOI：
10.1111/php.13551
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发表时间：
2022
影响因子：
3.3
通讯作者：
Cooke,MarcusS
中科院分区：
文献类型：
--
作者：
Lawrence,KarlP;Delinasios,GeorgeJ;Premi,Sanjay;Young,AntonyR;Cooke,MarcusS
一些早期的报告表明，环丁烷嘧啶二聚体（CPD）的水平可能会增加后，紫外线照射已经结束，虽然这些观察被视为文物。最近，已经明确表明CPD形成确实发生在辐照后，最大水平发生在约2-3小时后。这些病变被称为“暗CPD”（dCPD）。随后的研究证实了它们在体外、小鼠模型和人体皮肤中的存在。黑色素羰基在dCPD的形成中起作用，但它们也在无黑色素系统中观察到，表明存在其他未知的过程。在这两种情况下，dCPD的形成可以通过某些抗氧化剂的存在来防止。我们缺乏关于dCPD的光谱依赖性的数据，但它不太可能与仅在照射过程中形成的入射CPD（iCPD）相同。有证据表明iCPD和dCPD可能具有不同的修复动力学，尽管这仍有待阐明。目前还不清楚iCPD和dCPD是否具有不同的生物学特性。人体皮肤中dCPD的形成对日光暴露后的光保护和皮肤致癌作用有影响，需要进一步研究。
Some early reports demonstrate that levels of cyclobutane pyrimidine dimers (CPD) may increase after UVR exposure had ended, although these observations were treated as artifacts. More recently, it has been shown unequivocally that CPD formation does occur post‐irradiation, with maximal levels occurring after about 2–3 h. These lesions have been termed “dark CPD” (dCPD). Subsequent studies have confirmed their presencein vitro, in mouse models and in human skinin vivo. Melanin carbonyls have a role in the formation of dCPD, but they have also been observed in amelanotic systems, indicating other, unknown process(es) exist. In both cases, the formation of dCPD can be prevented by the presence of certain antioxidants. We lack data on the spectral dependence of dCPD, but it is unlikely to be the same as for incident CPD (iCPD), which are formed only during irradiation. There is evidence that iCPD and dCPD may have different repair kinetics, although this remains to be elucidated. It is also unknown whether iCPD and dCPD have different biological properties. The formation of dCPD in human skinin vivohas implications for post solar exposure photoprotection, and skin carcinogenesis, with a need for this to be investigated further.