Synthesis and preliminary pharmacological evaluation of coumestans with different patterns of oxygenation
Synthesis and preliminary pharmacological evaluation of coumestans with different patterns of oxygenation
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DOI：
10.1016/s0960-894x(00)00621-1
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发表时间：
2001-02-12
影响因子：
2.7
通讯作者：
Costa, PRR
中科院分区：
文献类型：
--
作者：
da Silva, AJM;Melo, PA;Costa, PRR
以间苯二酚和芳香醛为原料，合成了5个A、D环上不同氧化模式的古美斯坦，并对其抗心肌毒性进行了筛选。选择最有效的化合物(2b，IC_(50)=1微米)进行药理研究。(C)2001爱思唯尔科学有限公司。保留所有权利。
Five coumestans with different patterns of oxygenation in rings A and D were synthesized from resorcinol and aromatic aldehydes, and screened for their antimyotoxic activity. The most potent compound (2b, IC50= 1 muM) was selected for study of its pharmacological profile. (C) 2001 Elsevier Science Ltd. All rights reserved.