Regulation of inflammatory and antiviral signaling by A20.

Regulation of inflammatory and antiviral signaling by A20.
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DOI:
10.1016/j.micinf.2010.11.003
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发表时间:
2011-03
影响因子:
5.8
通讯作者:
Harhaj EW
Harhaj EW
中科院分区:
医学3区
文献类型:
--
作者:
Parvatiyar K;Harhaj EW

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去泛素化酶A20(也称为TNFAIP3)对维持免疫稳态至关重要。A20是炎症、抗病毒和凋亡信号通路的关键调节因子。在这里,我们回顾了最近的进展,说明A20作为炎症和抗病毒信号的重要负调节剂的作用。
The deubiquitinating enzyme A20 (also known as TNFAIP3) is essential for maintaining immune homeostasis. A20 is a key regulator of inflammatory, antiviral and apoptotic signaling pathways. Here, we review recent advances illustrating the role of A20 as an essential negative regulator of inflammatory and antiviral signaling.
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