Frequency-Domain Approach To Determine Magnetic Address-Sensor Separation Distance Using the Harmonic Ratio Method.
Frequency-Domain Approach To Determine Magnetic Address-Sensor Separation Distance Using the Harmonic Ratio Method.
复制标题
使用谐波比方法确定磁性地址传感器间隔距离的频域方法。
DOI：
10.1021/acs.analchem.5b04271
复制
发表时间：
2016
影响因子：
7.4
通讯作者：
Granger,MichaelC
中科院分区：
文献类型：
--
作者：
Young,ColinC;Blackley,BenjaminW;Porter,MarcD;Granger,MichaelC
在这项工作中，我们描述了一种确定磁地址与扫描磁阻传感器之间距离的方法，这是磁性纳米颗粒用作标记的某些生物测定分析的关键可调参数。我们的方法借鉴了谐波比方法（HRM），这是一种在硬盘驱动器行业中使用的方法，用于以纳米分辨率控制磁阻读磁头与其数据盘之间的距离。HRM的核心是对信号的基频与其谐波的幅度进行比较。当信号从磁地址周期阵列的磁场方向图导出时，谐波比包含确定地址阵列和读头之间的分离所必需的信息。人力资源管理的优雅之处在于，检测平台不需要额外的组件来确定分离距离；流的“位信号”包含了所有需要的信息。在这项工作中，我们证明了在硬盘驱动器行业中使用的管理人力资源管理的原则可以应用于需要亚微米至100 μm分离的生物分析领域。
In this work, we describe an approach to determine the distance separating a magnetic address from a scanning magnetoresistive sensor, a critical adjustable parameter for certain bioassay analyses where magnetic nanoparticles are used as labels. Our approach is leveraged from the harmonic ratio method (HRM), a method used in the hard drive industry to control the distance separating a magnetoresistive read head from its data platter with nanometer resolution. At the heart of the HRM is an amplitude comparison of a signal’s fundamental frequency to that of its harmonics. When the signal is derived from the magnetic field pattern of a periodic array of magnetic addresses, the harmonic ratio contains the information necessary to determine the separation between the address array and the read head. The elegance of the HRM is that there is no need of additional components to the detection platform to determine a separation distance; the streaming “bit signal” contains all the information needed. In this work, we demonstrate that the tenets governing HRM used in the hard drive industry can be applied to the bioanalytical arena where submicrometer to 100 μm separations are required.