THE VALIDITY OF RADIOLABELED ANTI FIBRIN ANTIBODY FOR DEEP-VEIN THROMBOSIS IMAGING
THE VALIDITY OF RADIOLABELED ANTI FIBRIN ANTIBODY FOR DEEP-VEIN THROMBOSIS IMAGING
复制标题
DOI：
10.1007/bf00252394
复制
发表时间：
1988-10-01
期刊：
影响因子：
--
通讯作者：
PAVLOVIC, S
中科院分区：
文献类型：
--
作者：
BOSNJAKOVIC, V;JANKOVIC, BD;PAVLOVIC, S
先前已经建立了一个新开发的放射性标记的多克隆抗纤维蛋白抗体（AFA）标记纤维蛋白沉积的特异性，临床实验验证这种代理成像深静脉血栓（DVT）进行了比较，标记的人血清白蛋白（HSA）和标记血小板。对DVT患者在计算机闪烁照相机上进行双示踪剂研究，其中4例同时应用131 I-AFA和99 mTc-HSA，8例同时应用131 I-AFA和111 In-血小板。结果表明：a）标记的AFA主要描绘血栓，而标记的HSA主要描绘特定静脉内的血池。B）发现标记的AFA在用于DVT成像的两种方式中均上级标记的血小板，即通过成像效果和通过半定量“血栓：血池”（以计数/像素获得）比率指数（RI）。用标记的AFA（9例患者）获得的平均RI和SD为2.44 ±。0.48和1.55 . ±. 0.27标记血小板（7例患者）。结果表明，单克隆AFA，如果用99 mTc，111 In或123 I标记，可能有潜力成为DVT显像的最佳试剂。
Having previously established the specificity of a newly developed radiolabeled polyclonal anti fibrin antibody (AFA) for tagging fibrin depositions, clinical experiments for validation of this agent for imaging deep vein thromboses (DVT) were carried out in comparison with labeled human serum albumin (HSA) and labeled platelets. Patients with DVT were studied with dual tracers on a computerized scintillation camera, four with simultaneous application of 131I-AFA and 99mTc-HSA, and eight with 131I-AFA and 111In-platelets. The results showed that: a) Labeled AFA predominantly delineated thrombi while labeled HSA prevailingly delineated blood pool within a particular vein. b) Labeled AFA was found to be superior in both ways to labeled platelets for DVT imaging, i.e. by imaging effect and by semiquantitative "thrombus:blood pool" (obtained in counts/pixel) ratio index (RI). Average RI with SD obtained with labeled AFA (9 patients) was 2.44 .+-. 0.48 and 1.55 .+-. 0.27 with labeled platelets (7 patients). The results indicate that a monoclonal AFA, if labeled with 99mTc, 111In or 123I, might have potential for an optimum agent for DVT imaging.