Virus Impact on Lipids and Membranes
Virus Impact on Lipids and Membranes
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DOI：
10.1146/annurev-virology-092818-015748
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发表时间：
2019-01-01
期刊：
影响因子：
--
通讯作者：
Randall, Glenn
中科院分区：
文献类型：
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作者：
Ketter, Ellen;Randall, Glenn
病毒在其生命周期的每个阶段操纵细胞脂质和膜。这包括脂质-受体相互作用、内吞作用期间病毒包膜与细胞膜的融合、细胞膜重组以形成复制区室以及病毒体的释放和排出。除了与细胞膜的物理相互作用外，病毒还进化为操纵脂质信号传导和代谢以利于其复制。本文综述了病毒在生命周期的各个阶段操纵脂质和膜的策略。
Viruses manipulate cellular lipids and membranes at each stage of their life cycle. This includes lipid-receptor interactions, the fusion of viral envelopes with cellular membranes during endocytosis, the reorganization of cellular membranes to form replication compartments, and the envelopment and egress of virions. In addition to the physical interactions with cellular membranes, viruses have evolved to manipulate lipid signaling and metabolism to benefit their replication. This review summarizes the strategies that viruses use to manipulate lipids and membranes at each stage in the viral life cycle.