Biomimetic, pH-Responsive Nanoplatforms for Cancer Multimodal Imaging and Photothermal Immunotherapy.
Biomimetic, pH-Responsive Nanoplatforms for Cancer Multimodal Imaging and Photothermal Immunotherapy.
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DOI：
10.1021/acsami.2c16667
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发表时间：
2022-12
影响因子：
9.5
通讯作者：
Li Wan;Yuting Cao;Chen Cheng;Rui Tang;Nianhong Wu;Yin Zhou;Xialing Xiong;Hongye He;
中科院分区：
文献类型：
--
作者：
Li Wan;Yuting Cao;Chen Cheng;Rui Tang;Nianhong Wu;Yin Zhou;Xialing Xiong;Hongye He;
光热疗法(PTT)是一种将光能转化为热能的新型非侵入性肿瘤热消融技术。然而，由于网状内皮细胞的吞噬作用，目前从外源性材料衍生的光热制剂(PTA)存在肿瘤靶向性差和内循环时间短的问题。由此造成的PTA在目标地区的积聚不足，严重降低了PTT的效力。此外，PTA的潜在毒性、过度的激光照射以及PTT后肿瘤复发和转移的可能性仍然是严重影响患者生活质量的难题。本文通过癌细胞膜包裹聚多巴胺(PDA)-CaCO3纳米粒子(CPCaNPs)制备了一种仿生pH响应型纳米探针，用于光声(PA)/超声(US)/热成像引导的PTT。当CPCaNPs靶向并渗透到肿瘤的酸性微环境中时，同源靶向CPCaNPs的分解产生的CO2气泡明显增强了超声(US)信号。同时，CPCaNPs的PDA不仅对原发肿瘤进行了有效的PTT，而且还产生了光声(PA)信号。此外，结合免疫检查点通路阻断，显著抑制了肿瘤的复发和转移，并在很大程度上改善了PTT后免疫抑制的微环境。因此，这些仿生pH响应型CPCaNPs在PA/US/热成像的智能引导下为精确PTT免疫治疗提供了一种有前景的策略，并显示出巨大的临床翻译潜力。
Photothermal therapy (PTT), by converting light to thermal energy, has become a novel and noninvasive technique for tumor thermal ablation in clinical practice. However, as a result of phagocytosis of reticuloendothelial cells, current photothermal agents (PTAs) derived from exogenous materials suffer from incompetent tumor targeting and brief internal circulation time. The resulting poor accumulation of PTAs in the target area severely reduces the efficacy of PTT. In addition, the potential toxicity of PTAs, excessive laser exposure, and possibilities of tumor recurrence and metastasis following PTT are still intractable problems that severely influence patients' quality of life. Herein, a biomimetic pH-responsive nanoprobe was prepared via cancer cell membrane coating polydopamine (PDA)-CaCO3 nanoparticles (CPCaNPs) for photoacoustic (PA)/ultrasonic (US)/thermal imaging-guided PTT. When CPCaNPs targeted and infiltrated into the tumor's acidic microenvironment, the decomposed CO2 bubbles from homologous targeting CPCaNPs enhanced ultrasonic (US) signals obviously. At the same time, the PDA of CPCaNPs not only performed efficient PTT of primary tumors but also generated photoacoustic (PA) signals. In addition, an immune checkpoint pathway blockade was combined, which inhibited tumor recurrence and metastasis significantly and improved the immunosuppressive microenvironment after PTT to a large extent. Thus, these proposed biomimetic pH-responsive CPCaNPs provide a promising strategy for precise PTT immunotherapy under the intelligent guidance of PA/US/thermal imaging and show great potential for clinical translation.