The response of the uterine surface to ovarian hormones in the aged rat.
The response of the uterine surface to ovarian hormones in the aged rat.
复制标题
老年大鼠子宫表面对卵巢激素的反应。
DOI：
10.1007/bf00303150
复制
发表时间：
1984
期刊：
影响因子：
--
通讯作者：
Jollie,WP
中科院分区：
文献类型：
--
作者：
Craig,SS;Jollie,WP
通过扫描电子显微镜对大鼠子宫腔上皮进行了研究，以确定年龄是否会改变卵巢激素刺激的子宫内膜表面部分的超微结构变化，其中植入发生在年轻的动物中。结果表明，在老年大鼠这一表面分化的卵巢激素的方式定性类似于发生在年轻的动物。卵巢切除大鼠的上皮细胞，无论是年轻的还是老年的，轮廓多边形，扁平，甚至有点凹，并有短微绒毛。雌激素处理后，两组细胞均呈圆形或椭圆形，并向管腔内隆起。幼鼠细胞表面覆盖长的微绒毛。老年大鼠大部分细胞的微绒毛长度相等或更长，少数上皮细胞的微绒毛数量较少且较短。雌二醇处理的青年和老年动物的细胞都被短的微绒毛覆盖，并有膜突起。在不同年龄组内和不同年龄组之间，突起的大小、形状和数量各不相同。这些结果表明，在表面超微结构的差异，老年子宫反映了年龄相关的变化激素水平。
By scanning electron microscopy uterine luminal epithelium of the rat was studied to determine whether aging alters ovarian hormone stimulated ultrastructural changes in that portion of the endometrial surface into which implantation takes place in the younger animal. Results show that in the aged rat this surface differentiates in response to ovarian hormones in a manner qualitatively similar to that which occurs in the young animal. Epithelial cells of ovariectomized rats, both young and aged, were polygonal in outline, flattened, or even somewhat concave, and had short microvilli. Following estrogen treatment cells of both groups were round or oval and bulged into the lumen. Cells of young rats were covered with long microvilli. Most cells of aged rats had microvilli of equal or greater length; a small number of epithelial cells had fewer and shorter microvilli. Cells of progesterone-treated young and aged animals both were covered with short microvilli and bore membrane protrusions. The protrusions varied in size, shape and numbers both within and between age groups. These findings suggest that differences in the surface ultrastructure of the aged uterus reflect age-related changes in hormone levels.