Human T cell antigen expression by primate T cells.
Human T cell antigen expression by primate T cells.
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灵长类 T 细胞表达人类 T 细胞抗原。
DOI：
10.1126/science.6171885
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发表时间：
1982
期刊：
影响因子：
--
通讯作者：
Metzgar,RS
中科院分区：
文献类型：
--
作者：
Haynes,BF;Dowell,DL;Hensley,LL;Gore,I;Metzgar,RS
11种单克隆抗体与人T细胞反应的灵长类系统发育研究以及灵长类T细胞与绵羊红细胞反应形成玫瑰花结的研究表明，绵羊红细胞受体和T细胞亚群抗原决定簇在灵长类进化过程中高度保守。其他T细胞抗原决定簇保守性较差。人类、大猩猩和黑猩猩的T细胞与抗人类T细胞的单克隆抗体表现出相同的反应性。灵长类T细胞表达人类T细胞抗原决定簇表明这组分子的进化速率恒定，并提供了额外的证据，证明人类和非洲猿有一个相对较近的共同祖先。
Phylogenetic study in primates of the reactivity of 11 monoclonal antibodies to human T cells and rosette formation in the reaction of primate T cells with sheep erythrocytes demonstrate that the sheep erythrocyte receptor and the determinants of T cell subset antigens are highly conserved during primate evolution. Other T cell antigen determinants are less well conserved. Human, gorilla, and chimpanzee T cells showed identical reactivity with the monoclonal antibodies to human T cells. The expression of human T cell antigen determinants by primate T cells suggests a constant rate of evolution for this group of molecules and provides additional evidence that man and African apes shared a relatively recent common ancestor.