Glucomannan, a promising polysaccharide for biopharmaceutical purposes
Glucomannan, a promising polysaccharide for biopharmaceutical purposes
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DOI：
10.1016/j.ejpb.2008.02.005
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发表时间：
2009-06-01
影响因子：
4.9
通讯作者：
Alonso, M. J.
中科院分区：
文献类型：
--
作者：
Alonso-Sande, M.;Teijeiro-Osorio, D.;Alonso, M. J.
在过去的几十年中，多糖在生物医学和药物递送领域获得了越来越多的关注。其中，葡甘露聚糖（GM）已成为一种特别有吸引力的聚合物。本文综述了转基因生物材料的物理化学和生物学特性，这些特性对转基因生物材料的开发具有决定性意义。这些性质包括结构组织、分子量、溶解度、粘度、胶凝性质和降解行为。此外，在本文中，我们分析了GM与其他亲水性聚合物相结合的可能性，以及GM的半合成衍生物的制备，这可能是在制药方面的利益。最后，我们讨论了转基因在药物传递领域的具体应用。(C)2008 Elsevier B.V.保留所有权利。
Over the last few decades, polysaccharides have gained increasing attention in the biomedical and drug delivery fields. Among them, glucomannan (GM), has become a particularly attractive polymer. In this paper, we review the physicochemical and biological properties which are decisive for the exploitation of GM as a biomaterial. These properties include the structural organization, molecular weight, solubility, viscosity, gelling properties and degradation behavior. Moreover, herein we analyze the possibilities of combining GM with other hydrophilic polymers, as well as the preparation of semisynthetic derivatives of GM, which may be of interest in the pharmaceutical context. Finally, we discuss the specific applications of GM in the drug delivery field. (C) 2008 Elsevier B.V. All rights reserved.