Elevated serum tumor necrosis factor-alpha concentrations and bioactivity in type 2 diabetics and patients with android type obesity
Elevated serum tumor necrosis factor-alpha concentrations and bioactivity in type 2 diabetics and patients with android type obesity
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DOI：
10.1016/s0168-8227(98)00109-0
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发表时间：
1998-12-01
影响因子：
5.1
通讯作者：
Cseh, K
中科院分区：
文献类型：
--
作者：
Winkler, G;Salamon, F;Cseh, K
在59名2型糖尿病患者、28名android型肥胖患者和35名健康瘦对照者中研究了肿瘤坏死因子-α在胰岛素抵抗中的作用。采用ELISA法和L979细胞毒生物测定法，每例患者5次，每8周重复测定血清肿瘤坏死因子-α的免疫反应浓度和生物活性，共12个月。与健康人相比，在2型糖尿病和肥胖组中均发现免疫反应性肿瘤坏死因子-α浓度和生物活性显著更高。两组患者的肿瘤坏死因子-α浓度和生物活性均与升高的基础血清C肽水平和体重指数呈显著正线性相关。根据这些数据，细胞因子可能在肥胖症和2型糖尿病的胰岛素抵抗中发挥作用。(C)1998爱思唯尔科学爱尔兰有限公司保留所有权利。
The role of tumor necrosis factor-alpha in insulin resistance has been studied in 59 patients with Type 2 diabetes, 28 with android type obesity and 35 healthy lean controls. Immunoreactive concentrations and bioactivity of serum tumor necrosis factor-alpha have repeatedly been determined in 8 weeks intervals for 12 months, five times per patients, by using ELISA and L979 cell cytotoxicity bioassay. Significantly higher immunoreactive tumor necrosis factor-alpha concentrations and bioactivity have been found in both, the Type 2 diabetic and obese groups as compared to the healthy persons. Tumor necrosis factor-alpha concentrations and bioactivity have showed a significant positive linear correlation with the elevated basal serum C-peptide levels and body mass indexes in both groups of patients. According to these data the cytokine might play a role in insulin resistance in obesity as well in Type 2 diabetes. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.