Morphological study of the phrenic nerve to determine a reference value for the myelinated fiber density in elderly individuals
Morphological study of the phrenic nerve to determine a reference value for the myelinated fiber density in elderly individuals
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膈神经形态学研究以确定老年人有髓纤维密度的参考值
DOI：
10.1111/neup.12856
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发表时间：
2022
期刊：
影响因子：
2.3
通讯作者：
Murayama Shigeo
中科院分区：
文献类型：
--
作者：
Motoda Atsuko;Matsubara Tomoyasu;Tanei Zen‐ichi;Sakashita Yasuhiro;Yamazaki Mikihiro;Kawakami Ito;Sengoku Renpei;Arai Tomio;Maruyama Hirofumi;Saito Yuko;Murayama Shigeo
膈神经（PN）在呼吸中起着重要的作用;然而，很少有形态学研究评估它们。本研究旨在为今后的病理学研究提供对照参考值，包括大小有髓PN纤维的密度。我们评估了2018年至2019年期间在脑库老龄化研究中登记的8例连续尸检病例中的9条神经（5男3女，平均年龄77.0±7.0岁）。从远端对神经进行取样，并使用甲苯胺蓝染色的半薄切片分析其结构。PN的每根有髓纤维密度的平均值和标准差分别为6908±1132根纤维/mm 2（总有髓纤维）、4095±586根纤维/mm 2（大直径有髓纤维;直径≥ 7 μm）和2813±629根纤维/mm 2（小直径有髓纤维;直径< 7 μm）。有髓纤维密度与年龄无相关性。本研究提供了人PN有髓纤维的密度测量结果，这些结果可作为老年人PN的参考值。
Phrenic nerves (PNs) play an important role in respiration; however, very few morphological studies have assessed them. This study aimed to provide control reference values, including the density of large and small myelinated PN fibers, for future pathological studies. We assessed a total of nine nerves from eight cases among consecutive autopsy cases registered to the Brain Bank for Aging Research between 2018 and 2019 (5 men and 3 women, mean age 77.0±7.0 years). The nerves were sampled distally, and their structures were analyzed using semi-thin sections stained with toluidine blue. The mean and standard deviation of the density of each myelinated fiber of the PN was 6908±1132 fibers/mm2 (total myelinated fiber), 4095±586 fibers/mm2 (large diameter myelinated fiber; diameter≥ 7 μm), and 2813±629 fibers/mm2 (small diameter myelinated fiber; diameter< 7 μm). There was no correlation between myelinated fiber density and age. This study provides the density measurement of the human PN myelinated fiber, and these findings can be used as reference values for the PN in elderly individuals.