Retinal Vein Occlusion and the Risk of Stroke Development: A Five-year Follow-up Study
Retinal Vein Occlusion and the Risk of Stroke Development: A Five-year Follow-up Study
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DOI：
10.1016/j.ajo.2008.08.006
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发表时间：
2009-02-01
影响因子：
4.2
通讯作者：
Lin, Herng-Ching
中科院分区：
文献类型：
--
作者：
Ho, Jau-Der;Liou, Shiow-Wen;Lin, Herng-Ching
目的：探讨视网膜静脉闭塞（RVO）发生后发生脑卒中的风险。设计：以全国人口为基础的回顾性行政数据库研究。方法：资料采自台湾全民健保研究资料库，随机纳入2,300万台湾居民1,073,891名受试者。研究队列包括1999年1月至2001年12月首次诊断为中枢性或分支性RVO的所有患者（n = 350）。比较队列由随机选择的患者（n = 2100）组成，这些患者在年龄、性别和门诊就诊日期上与研究组相匹配。每个样本患者都被追踪了5年。在对可能的混杂因素进行校正后，采用Cox比例风险回归来计算5年无卒中生存率。结果：RVO患者和对照组患者卒中发生率分别为35.1%和19.9%。在调整人口统计学特征和合并症后，在任何年龄的受试者中，RVO与卒中发生风险增加无关（调整后的风险比为1.01；95%可信区间[CI]， 0.65至1.57）。然而，60至69岁的RVO患者发生卒中的风险高出2.34倍（95% CI， 1.05至5.24）。结论：除了60至69岁的亚组外，RVO与卒中没有总体关联。可能的原因包括：60岁至69岁年龄组中风的风险实际上增加了，偶然发现，存在选择偏差，70岁年龄组中风患者人数较少。[J] .中华眼科杂志，2009;47(1):393 - 398。(C) 2009年Elsevier Inc.版权所有。)
PURPOSE: To investigate the risk of stroke development following the occurrence of retinal vein occlusion (RVO).DESIGN: Retrospective nationwide population-based administrative database study.METHODS: Data were collected from Taiwan National Health Insurance Research Database, which comprises 1,073,891 random subjects from 23 million Taiwan residents. The study cohort comprised of all patients with a first-time diagnosis of either central or branch RVO from January 1999 to December 2001 (n = 350). The comparison cohort comprised randomly selected patients (n = 2,100) matched with the study group for age, gender, and the date of ambulatory care visit. Each sampled patient was tracked for five years. Cox proportional hazard regressions were utilized to compute the five-year stroke-free survival rate after adjusting for possible confounding factors.RESULTS: Stroke developed in 35.1% and 19.9% of RVO patients and comparison group patients, respectively. After adjusting for demographic characteristics and comorbidities, RVO was not associated with an increased risk of stroke development (adjusted hazard ratio, 1.01; 95% confidence interval [CI], 0.65 to 1.57) among subjects of any age. However, RVO patients age 60 to 69 years had a 2.34-fold (95% CI, 1.05 to 5.24) higher risk of suffering a stroke.CONCLUSIONS: There was no overall association of RVO with stroke except in the 60 to 69,year subgroup. The possible causes include: an actually increased risk of stroke development in the 60 to 69 year group, chance finding, the presence of selection biases, small numbers of stroke patients in the = 70-year group. (Am J Ophthalmol 2009;147:283-290. (C) 2009 by Elsevier Inc. All rights reserved.)