Detoxification of amyloid β fibrils by curcumin derivatives and their verification in a <i>Drosophila</i> Alzheimer's model
Detoxification of amyloid β fibrils by curcumin derivatives and their verification in a <i>Drosophila</i> Alzheimer's model
复制标题
姜黄素衍生物对淀粉样β原纤维的解毒作用及其在果蝇阿尔茨海默病模型中的验证
DOI：
10.1039/d1cc07000b
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发表时间：
2022
影响因子：
4.9
通讯作者：
Nakamura Hiroyuki
中科院分区：
文献类型：
--
作者：
Utomo Rohmad Yudi;Sugie Atsushi;Okada Satoshi;Miura Kazuki;Nakamura Hiroyuki
姜黄素衍生物B和N作为β淀粉样蛋白（Aβ）纤维的解聚剂被开发。在神经母细胞瘤细胞中观察到每种化合物在1 μM浓度下提供的解毒作用。此外，这两种化合物在表达Aβ的果蝇阿尔茨海默病模型中显著挽救了运动功能障碍。
Curcumin derivatives B and N were developed as disaggregation agents of amyloid β (Aβ) fibrils. The detoxification provided by each compound at a concentration of 1 μM was observed in neuroblastoma cells. Furthermore, both compounds significantly rescued locomotion dysfunction in an Aβ-expressing Drosophila model of Alzheimer's disease.