Squamous Cell Cancers: A Unified Perspective on Biology and Genetics.
Squamous Cell Cancers: A Unified Perspective on Biology and Genetics.
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DOI：
10.1016/j.ccell.2016.04.004
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发表时间：
2016-05-09
期刊：
影响因子：
50.3
通讯作者：
Rustgi AK
中科院分区：
文献类型：
--
作者：
Dotto GP;Rustgi AK
鳞状细胞癌（SCCs）是最常见的人类实体肿瘤，也是癌症死亡的主要原因。这些高度异质性的肿瘤起源于紧密相连的上皮细胞群，具有内在的自我更新潜力，与分层分化程序成反比。SCCs也可以通过激活静止细胞和/或细胞命运决定的开关而起源于简单或伪分层上皮。在这里，我们通过最近的大规模基因组学、遗传学和表观遗传学研究以及互补功能分析，重点关注与SCCs发展有关的特定决定因素。这一证据表明，来自不同身体部位的SCCs虽然在临床上被视为独立的实体，但具有共同的决定因素，这表明了对该疾病的统一看法和潜在的预防和治疗新途径。
Squamous cell carcinomas (SCCs) represent the most frequent human solid tumors and a major cause of cancer mortality. These highly heterogeneous tumors arise from closely interconnected epithelial cell populations with intrinsic self-renewal potential inversely related to the stratified differentiation program. SCCs can also originate from simple or pseudo-stratified epithelia through activation of quiescent cells and/or a switch in cell fate determination. Here, we focus on specific determinants implicated in the development of SCCs by recent large-scale genomic, genetic and epigenetic studies and complementary functional analysis. This evidence indicates that SCCs from various body sites, while clinically treated as separate entities, have common determinants, pointing to a unified perspective of the disease and potential new avenues for prevention and treatment.