Interpregnancy Interval and Anti-inflammatory Cervical Cytokines among Women with Previous Spontaneous Preterm Birth.
Interpregnancy Interval and Anti-inflammatory Cervical Cytokines among Women with Previous Spontaneous Preterm Birth.
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既往自然早产妇女的妊娠间隔和抗炎宫颈细胞因子。
DOI：
10.1055/s-0034-1395478
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发表时间：
2015
影响因子：
2
通讯作者：
Simhan,HyagrivN
中科院分区：
文献类型：
--
作者：
Shree,Raj;Simhan,HyagrivN
目的自发性早产（sPTB）史和较短的妊娠间隔（IPIs）都会增加复发性早产的风险。 IPI 与复发性 sPTB 之间关联的机制尚不清楚。我们之前已经证明，较高浓度的宫颈抗炎细胞因子是 sPTB 和上生殖道炎症的危险因素。在这里，我们检查了既往 sPTB 女性中 IPI 与宫颈抗炎细胞因子之间的关联。患者和方法 73 名既往 sPTB 女性的前瞻性队列，在 16 周时测量宫颈白细胞介素（IL-4、IL-10 和 IL-13）。使用已发表的主因素分析，计算抗炎（ANTI）评分。根据我们之前的工作，较高的 ANTI 分数会增加随后发生 sPTB 的风险。 IPI是从上一次出生到本次怀孕的时间。混杂因素包括教育水平、婚姻状况、淋病、衣原体、体重指数、种族和吸烟情况。采用单变量和多变量分析方法对IPI和ANTI评分进行分析。结果IPI和ANTI评分之间存在显着的负线性关系(β=-0.075,p= 0.017)。在调整混杂因素后，这种情况仍然存在（p= 0.02）。随着 IPI 降低 1 个月，与 ANTI 评分相关的 sPTB 风险增加约 4%。 结论 在既往有 sPTB 的女性中，IPI 和 ANTI 评分之间存在显着的负线性关系。
ObjectiveBoth history of spontaneous preterm birth (sPTB) and shorter interpregnancy intervals (IPIs) increase the risk of recurrent sPTB. Mechanisms underlying the association between IPI and recurrent sPTB are unknown. We have previously demonstrated that higher concentrations of cervical anti-inflammatory cytokines are a risk factor for sPTB and upper genital tract inflammation. Here, we examine the association between IPI and cervical anti-inflammatory cytokines among women with previous sPTB.Patients and MethodsA prospective cohort of 73 women with previous sPTB and cervical interleukins (IL-4, IL-10, and IL-13) measured at < 16 weeks. Using the published principal factor analysis, the anti-inflammatory (ANTI) score was calculated. From our previous work, higher ANTI scores increase the subsequent risk of sPTB. IPI was the time from the previous birth to the conception of current pregnancy. Confounders included education level, marital status, gonorrhea, chlamydia, body mass index, race, and cigarette smoking. IPI and ANTI score were analyzed using univariable and multivariable analyses.ResultsThere was a significant negative linear relation between IPI and ANTI score (β = −0.075,p= 0.017). This persisted after adjustment for confounders (p= 0.02). As IPI decreases by 1 month, the ANTI-score–associated risk of sPTB increases approximately by 4%.ConclusionAmong women with previous sPTB, there was a significant negative linear relation between IPI and ANTI score.