Exchange donor program in kidney transplantation
Exchange donor program in kidney transplantation
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DOI：
10.1097/00007890-199901270-00027
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发表时间：
1999-01-27
期刊：
影响因子：
6.2
通讯作者：
Kim, YS
中科院分区：
文献类型：
--
作者：
Park, K;Moon, JI;Kim, YS
捐献器官短缺一直是韩国肾移植的主要障碍之一，尽管在过去十年中有少量但稳定的尸体肾捐献。为了扩大肾移植的供体库，我们在我们的机构和韩国制定了交换供体计划。供者交换计划首先开始于终末期肾病患者，他们有意愿但由于淋巴细胞交叉配型阳性而不相容的亲属供者。采用两个家庭交换的肾脏进行肾移植，结果成功。自从这一成功以来，我们通过接受者的近亲、配偶、朋友和自愿捐赠者作为交换捐赠者的候选人，并通过仔细的捐赠者筛选程序，扩大了捐赠者库。这有助于缓解捐赠者供应的压力。特别是在那些脑死亡尚未被社会或法律接受的国家，活体捐赠者，包括亲属，非亲属和交换捐赠者，应被视为肾移植的潜在捐赠者，以减轻捐赠器官短缺的压力。
The donor organ shortage has been one of the major barriers to kidney transplantation in Korea, even though there has been a small but steady flow of cadaveric kidney donations for the last decade. To expand the donor pool in kidney transplantation, we have developed the exchange donor program at our institution and in Korea. The donor exchange program was first started for end-stage renal disease patients who had willing but incompatible related donors due to positive lymphocyte cross-match. The kidney transplantations were performed using exchanged kidneys between two families with successful results. Since this success, we have expanded the donor pool by accepting close relatives, spouses, friends of recipients, and willing voluntary donors as candidates for exchange donors with careful donor screening procedures. It helps relieve stress on donor supply. Particularly in those countries where brain death has not been socially or legally accepted, living donors including related, unrelated, and exchange donors should be considered as potential donors for kidney transplantation to relieve the pressure on donor organ shortage.