Changing your sex changes your brain: influences of testosterone and estrogen on adult human brain structure
Changing your sex changes your brain: influences of testosterone and estrogen on adult human brain structure
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DOI：
10.1530/eje.1.02248
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发表时间：
2006-11-01
影响因子：
5.8
通讯作者：
Kahn, Rene S.
中科院分区：
文献类型：
--
作者：
Hulshoff Pol, Hilleke E.;Cohen-Kettenis, Peggy T.;Kahn, Rene S.
目的：性激素不仅参与生殖器官的形成，而且还诱导大脑的性别发育和组织。跨性别激素管理变性人提供了一个独特的可能性，研究性类固醇对大脑形态的影响，在年轻的成年人。磁共振脑成像之前，和期间，研究抗雄激素+雌激素治疗对8名年轻成年男变女变性人受试者脑形态学的影响，以及雄激素治疗对6名女变女变性人受试者脑形态学的影响。结果：与对照组相比，抗雄激素+雌激素治疗使男性变女性受试者的脑体积减少，接近女性比例，而雄激素治疗使女性变男性受试者的总脑和下丘脑体积增加，接近男性比例。研究结果表明，在整个生命过程中，性腺激素对于维持人类大脑中性别特异性差异的各个方面仍然至关重要。
Objective: Sex hormones are not only involved in the formation of reproductive organs, but also induce sexually-dimorphic brain development and organization. Cross-sex hormone administration to transsexuals provides a unique possibility to study the effects of sex steroids on brain morphology in young adulthood.Methods: Magnetic resonance brain images were made prior to, and during, cross-sex hormone treatment to study the influence of anti-androgen+estrogen treatment on brain morphology in eight young adult male-to-female transsexual human subjects and of androgen treatment in six female-to-male transsexuals.Results: Compared with controls, anti-androgen+ estrogen treatment decreased brain volumes of male-to-female subjects towards female proportions, while androgen treatment in female-to-male subjects increased total brain and hypothalamus volumes towards male proportions.Conclusions: The findings suggest that, throughout life, gonadal hormones remain essential for maintaining aspects of sex-specific differences in the human brain.