1'S-1'-acetoxychavicol acetate as a new type inhibitor of interferon-β production in lipopolysaccharide-activated mouse peritoneal macrophages
1'S-1'-acetoxychavicol acetate as a new type inhibitor of interferon-β production in lipopolysaccharide-activated mouse peritoneal macrophages
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DOI：
10.1016/j.bmc.2005.02.022
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发表时间：
2005-05-02
影响因子：
3.5
通讯作者：
Yoshikawa, M
中科院分区：
文献类型：
--
作者：
Ando, S;Matsuda, H;Yoshikawa, M
已知高良姜根茎中的1‘S-1’-乙酰氧基查维酮醋酸酯对内毒素激活的小鼠巨噬细胞产生一氧化氮(NO)有明显的抑制作用。为阐明其作用机制，观察了1‘S-1’-乙酰氧基查维酮醋酸酯对内毒素激活的巨噬细胞中参与诱导型一氧化氮合酶诱导的干扰素-β基因表达和核转录因子-kappaB活性的影响。并与两种核因子-kappaB激活抑制剂--木犀草素内酯和咖啡酸苯乙酯的结果进行了比较。1‘-S-1’-乙酰氧基乙酸酯可抑制干扰素-β基因的表达和核因子-kappaB的激活，相关化合物(+/-)-1-乙酰氧基-1-(2-乙酰氧基苯基)-2-丙烯和(+/-)-1-乙酰氧基-1-(4-乙酰氧基苯酚)-3-丁烯也能抑制干扰素-β基因的表达。此外，1‘S-1’-乙酰氧基乙酸酯通过Toll样受体3抑制聚(I：C)刺激的NO的产生。(C)2005年爱思唯尔有限公司。版权所有。
1'S-1'-Acetoxychavicol acetate from the rhizomes of Alpinia galanga was known to show potent inhibitory effect on the production of nitric oxide (NO) in lipopolysaccharide-activated mouse peritoneal macrophages. To clarify its mechanism of action, the effects of 1'S-1'-acetoxychavicol acetate on the expression of interferon-beta (IFN-beta) mRNA and activation of nuclear factor-kappa B (NF-kappa B), both of which participate in the induction of inducible NO synthase, were examined in lipopolysaccharide-activated macrophages. The results were compared with those of two inhibitors of the NF-kappa B activation, costunolide and caffeic acid phenethyl ester. 1'S-1'-Acetoxychavicol acetate inhibited IFN-beta mRNA expression as well as NF-kappa B activation, and two related compounds, (+/-)-1-acetoxy-1-(2-acetoxyphenyl)-2-propene and (+/-)-1-acetoxy-1-(4-acetoxyphenol)-3-butene, also inhibited IFN-beta mRNA expression. In addition, 1'S-1'-acetoxychavicol acetate inhibited the production of NO stimulated by poly(I:C) via Toll-like receptor 3. (c) 2005 Elsevier Ltd. All rights reserved.