Effects of prenatal spaceflight on vestibular responses in neonatal rats.
Effects of prenatal spaceflight on vestibular responses in neonatal rats.
复制标题
产前太空飞行对新生大鼠前庭反应的影响。
DOI：
10.1152/jappl.2000.89.6.2318
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发表时间：
2000
期刊：
影响因子：
--
通讯作者：
Alberts,JR
中科院分区：
文献类型：
--
作者：
Ronca,AE;Alberts,JR
Ten pregnant Norway rats(Rattus norvegicus)were flown for 11 days on board the NASA space shuttle from gestationalday 9(launch) until gestationalday 20(landing) of the rats' 22-day pregnancy. After the birth of the pups, vestibular responses were analyzed from postnatalday(P)0until P5. In the first test, P0 neonates were supported on a platform in a side-lying position. Skyward head movements (i.e., movements performed against the gravity vector) were more frequent than head movements toward Earth in both flight and control neonates. In the second test, the contact-righting reflex, composed of stereotyped movements that rotate the body from supine to prone on a solid surface, was analyzed in P0 neonates. The frequency and latency of contact-righting responses did not differ in flight and control neonates. In the third test, vestibular head righting, with tactile and proprioceptive cues removed, was tested in neonates on P1, P3, and P5 by using a water-immersion test. Righting responses were observed less frequently in P1 and P3 flight neonates compared with controls. However, this deficit was transient, as evidenced by complete response recovery on P5. Collectively, these findings provide evidence for a selective disruption of vestibular-mediated responses after prenatal exposure to spaceflight.
