Effects of ω-3 Essential Fatty Acids (ω-3 EFAs) on Motor Disorders and Memory Dysfunction Typical Neuroleptic-induced: Behavioral and Biochemical Parameter
Effects of ω-3 Essential Fatty Acids (ω-3 EFAs) on Motor Disorders and Memory Dysfunction Typical Neuroleptic-induced: Behavioral and Biochemical Parameter
复制标题
ω-3 必需脂肪酸 (ω-3 EFA) 对运动障碍和记忆功能障碍的影响典型抗精神病药引起的：行为和生化参数
作者：
R. Barcelos;D. Benvegnú;N. Boufleur;P. Reckziegel;L. Müller;C. Pase;T. Emanuelli;M. Bürger
研究了补充鱼油对典型抗精神病药引起的运动障碍、记忆功能障碍和脂质过氧化（LP）的影响。 Wistar 大鼠接受用含有 ω-3 脂肪酸的鱼油、水和 Tween 80 (1%) 制备的悬浮液代替饮用水（FO 组）或媒介物（C 组），持续 8 周。治疗 4 周后，两组动物的一半接受氟哌啶醇（H 和 FO + H 组；实验 1）、氟奋乃静（F 和 FO + F 组；实验 2）或媒介物（C 组）治疗，每周一次（12 mg/kg/im），持续 4 周，维持 FO 治疗。通过观察氟哌啶醇和氟奋乃静引起的锥体外系运动障碍，空虚性咀嚼运动和僵硬症增加（P < 0.05）。 FO 治疗可减少这些影响 (P < 0.05)。在最后一个治疗周进行 4 天的训练后，通过在水迷宫任务中找到平台原始位置的潜伏时间观察到，这两种精神安定药都表现出记忆保留受损的情况。氟哌啶醇和氟奋乃静治疗均通过 FO（P < 0.05）降低了这种效果。氟哌啶醇增加了血浆和海马中的 LP，而 FO 治疗则降低了这些作用 (P < 0.05)。氟奋乃静增加了血浆和黑质中的 LP，而 FO 治疗完全降低了 LP（P < 0.05）。 FO 减少了典型的抗精神病药引起的运动障碍、记忆功能障碍和氧化损伤。我们的结果表明，FO 对氧化损伤相关疾病具有神经保护作用，并且可以考虑用于预防抗精神病药物治疗引起的运动和记忆副作用。
The effects of fish oil supplementation on motor disorders, memory dysfunction, and lipid peroxidation (LP) induced by typical neuroleptics were studied. Wistar rats received a suspension prepared with fish oil containing ω-3 fatty acids, water, and Tween 80 (1%) in the place of drinking water (FO group) or vehicle (C group) for 8 weeks. After 4 weeks of treatment, half of the animals of both groups were treated with haloperidol (H and FO + H groups; experiment 1), fluphenazine (F and FO + F groups; experiment 2), or vehicle (C group), administered once a week (12 mg/kg/im) for 4 weeks, maintaining the treatment with FO. Extrapyramidal motor disorders by haloperidol and fluphenazine were observed by an increase in vacuous chewing movements and catalepsy (P < 0.05). These effects were reduced by FO treatment (P < 0.05). Both neuroleptics displayed impairment in memory retention observed by latency time to find the original location of platform in water-maze task, after 4 days of training performed in the last treatment week. This effect was reduced by FO (P < 0.05) to both haloperidol and fluphenazine treatments. Haloperidol increased the LP in plasma and hippocampus, and these effects were decreased by FO treatment (P < 0.05). Fluphenazine increased the LP in plasma and substantia nigra, which were completely decreased by FO treatment (P < 0.05). The FO decreased the motor disorders, memory dysfunction, and oxidative damage typical neuroleptic-induced. Our results indicate that FO exhibits a neuroprotector role useful on diseases related to oxidative damages, and may be considered in the prevention of motor and memory side effects induced by the antipsychotic treatment.
欧米伽 3 脂肪酸的重要性：来自灵长类动物模型的证据及其对人类营养的影响。
影响因子：
--
作者：
Connor,WE;Neuringer,M;Reisbick,S
通讯作者：
Reisbick,S
影响因子：
4.8
作者：
Parikh, V;Khan, MM;Mahadik, SP
通讯作者：
Mahadik, SP