Eliminating molybdenum oxide interference in urine cadmium biomonitoring using ICP-DRC-MS
Eliminating molybdenum oxide interference in urine cadmium biomonitoring using ICP-DRC-MS
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DOI：
10.1039/b801927d
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发表时间：
2008-01-01
影响因子：
3.4
通讯作者：
Jones, Robert L.
中科院分区：
文献类型：
--
作者：
Jarrett, Jeffery M.;Xiao, Ge;Jones, Robert L.
提出了一种新的尿镉生物监测方法。采用电感耦合等离子体动态反应细胞质谱仪(ICP-DRC-MS)消除钼多原子干扰。从2003-2004年的调查周期开始，该方法开始用于国家健康和营养检查调查(NHANES)。对于NHANES 2003-2004年的尿样子集(N=2066)，去除基于钼的多原子干扰被发现可以显著降低观察到的尿镉浓度，在第50个百分位数处降低37%。为避免引入这种方法对NHANES数据造成人为偏移，在根据以前确定的钼浓度对偏差进行数学校正后，重新公布了1999-2000年和2001-2002年调查周期的尿镉结果(www.cdc.gov/exposurereport/report.htm，(1)www.cdc.gov/nchs/datawh.htm(2))。文中给出了支持这种数学平差的数据。本文提供的血镉数据显示，在正常的血钼水平下，没有观察到明显的钼基干扰。
A new method for urine cadmium biomonitoring is presented. It uses inductively coupled plasma dynamic reaction cell mass spectrometry (ICP-DRC-MS) to eliminate molybdenum-based polyatomic interferences. The method began to be used in the National Health and Nutrition Examination Survey (NHANES) starting with the 2003-2004 survey cycle. Removal of moybdenum-based polyatomic interferences was found to reduce observed urine cadmium concentrations by a signficant amount, 37% at the 50(th) percentiles, for a subset (N = 2066) of NHANES 2003-2004 urine specimens. To avoid creating an artificial shift in NHANES data with the introduction of this method, urine cadmium results for survey cycles 1999-2000 and 2001-2002 were republished (www.cdc.gov/exposurereport/report.htm,(1) www.cdc.gov/nchs/datawh.htm(2)) after mathematical adjustment correcting for the bias on the basis of their previously determined molybdenum concentrations. Data supporting this mathematical adjustment are presented in this article. Blood cadmium data presented here show that at the normal levels of blood molybdenum, no significant molybdenum-based interferences are observed.