Neighborhood social capital and incidence and mortality of prostate cancer: a Swedish cohort study
Neighborhood social capital and incidence and mortality of prostate cancer: a Swedish cohort study
复制标题
DOI：
10.1007/s40520-021-01852-9
复制
发表时间：
2021-04-22
影响因子：
4
通讯作者：
Sundquist, Kristina
中科院分区：
文献类型：
--
作者：
Hamano, Tsuyoshi;Li, Xinjun;Sundquist, Kristina
背景人们对社区联系社会资本对包括癌症在内的不同健康结果的背景影响的兴趣与日俱增。旨在研究社区社会资本与前列腺癌发病率和死亡率之间的关系。方法以国家登记资料为基础进行队列研究。在2002年至2015年期间，我们将1196563名50岁及以上的男性纳入分析范围。多水平Logistic回归被用来估计暴露与结果之间的关联的优势比(OR)和95%可信区间(CI)，调整了潜在的混杂因素。结果前列腺癌总发病率为8.22/100，病死率为1.80/100。低(OR 0.90；95%CI 0.88~0.93)和中等(OR 0.94；95%CI 0.92~0.96)联系社会资本的社区比高联系社会资本的社区更不容易患前列腺癌。对死亡率的影响则相反；生活在低(OR 1.15；95%CI 1.08~1.23)和中等(OR 1.09；95%CI 1.03~1.14)社会资本链接的社区的前列腺癌患者比那些链接社会资本高的社区的患者更容易死于前列腺癌。结论联系社会资本的社区越低，前列腺癌患者的发病率越低，死亡率越高。这些发现表明，生活在链接社会资本较低的社区的男性可能需要额外监测前列腺癌。
Background There is a growing interest in the contextual effect of neighborhood linking social capital on different health outcomes, including cancer. Aims To examine associations between neighborhood linking social capital and incidence and mortality of prostate cancer. Method This cohort study was based on national registers. Between 2002 and 2015, we included 1,196,563 men aged 50 years and above in the analyses. Multilevel logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CI) for the association between exposure and outcome, adjusting for potential confounding factors. Results The total incidence of prostate cancer and mortality in patients with prostate cancer were 8.22 (per 100) and 1.80 (per 100), respectively, during the follow-up period. Individuals living in neighborhoods with low (OR 0.90; 95% CI 0.88-0.93) and intermediate (OR 0.94; 95% CI 0.92-0.96) linking social capital were less likely to be diagnosed with prostate cancer than those living in neighborhoods with high linking social capital. Opposite effects were observed for mortality; prostate cancer patients living in neighborhoods with low (OR 1.15; 95% CI 1.08-1.23) and intermediate (OR 1.09; 95% CI 1.03-1.14) linking social capital were more likely to die from prostate cancer than those in neighborhoods with high linking social capital. Conclusions Lower neighborhood linking social capital was associated with lower incidence but higher mortality in patients with prostate cancer. These findings suggest that men living in neighborhoods with low linking social capital may need additional surveillance for prostate cancer.