METABOLIC CLEARANCE RATE AND BLOOD PRODUCTION RATE OF TESTOSTERONE AND DIHYDROTESTOSTERONE IN NORMAL SUBJECTS, DURING PREGNANCY, AND IN HYPERTHYROIDISM
METABOLIC CLEARANCE RATE AND BLOOD PRODUCTION RATE OF TESTOSTERONE AND DIHYDROTESTOSTERONE IN NORMAL SUBJECTS, DURING PREGNANCY, AND IN HYPERTHYROIDISM
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DOI：
10.1172/jci106917
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发表时间：
1972-01-01
影响因子：
15.9
通讯作者：
FOREST, MG
中科院分区：
文献类型：
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作者：
SAEZ, JM;BERTRAND, J;FOREST, MG
本文研究了睾酮（T）和双氢睾酮（DHT）的代谢清除率（MCR）和血液生成率（BP），血浆睾酮向血浆双氢睾酮的转化，以及雄烯二酮、睾酮和双氢睾酮的肾清除率。MCRT（516±108 [SD]升/m2/天）显著大于MCRDHT（391±71 [SD]升/m2/天）。在7名女性中，MCRT（304±53 [SD]升/m2/天）也大于MCRDHT（209±45 [SD]升/m2/天），两个值均小于男性的相应值（P< 0.001）。男性睾酮转化为双氢睾酮的比率为2.8±0.3%（SD），高于女性的1.56±0.5%（SD）（P< 0.001）。在5只妊娠雌性动物中，MCRT（192±36 [SD] L/m2/d）、MCRDHT（89±30 [SD] L/m2/d）和睾酮转化为双氢睾酮（0.72±0.15%）（SD）均显著低于非妊娠雌性动物的数值。在5例甲亢女性中，睾酮和双氢睾酮的MCR与妊娠女性中观察到的相似，但睾酮转化为双氢睾酮（2.78±1.7%）（SD）更高，与男性相似。在男性中，双氢睾酮的产生量为0.39±0.1（SD）mg/天，50%来自血浆睾酮的转化。在女性中，DHT的产生为0.05±0.028（SD）mg/天，只有10%来自睾酮。在怀孕期间，睾酮和双氢睾酮的产生与正常女性相似。在3例睾丸女性化综合征患者（1例甲亢成人和2例儿童）中，雄烯二酮和双氢睾酮的MCR均较正常女性显著降低，但睾酮向双氢睾酮的转化仍在正常男性的范围内。尿中少于20%的二氢睾酮和少于10%的雄烯二酮来自血浆二氢睾酮和雄烯二酮。
The metabolic clearance rate (MCR) and blood production rate (BP) of testosterone (T) and dihydrotestosterone (DHT), the conversion of plasma testosterone to plasma dihydrotestosterone, and the renal clearance of androstenedione, testosterone, and dihydrotestosterone have been studied in man. In eight normal men, the MCRT(516±108 [SD] liters/m2/day) was significantly greater than the MCRDHT(391±71 [SD] liters/m2/day). In seven females, the MCRT(304±53 [SD] liters/m2/day) was also greater than the MCRDHT(209±45 [SD] liters/m2/day) and both values were less than their respective values in men (P< 0.001). In men the conversion of testosterone into dihydrotestosterone at 2.8±0.3% (SD) was greater than that found in females, 1.56±0.5% (SD) (P< 0.001). In five pregnant females the MCRT(192±36 [SD] liters/m2/day), the MCRDHT(89±30 [SD] liters/m2/day) and the conversion of testosterone into dihydrotestosterone (0.72±0.15%) (SD) were significantly less than the values found in nonpregnant women. In five females with hyperthyroidism, the MCR for testosterone and dihydrotestosterone were similar to those observed in pregnant females, but the conversion of testosterone into dihydrotestosterone (2.78±1.7%) (SD) was greater, and similar to that found in men. In men the production of dihydrotestosterone was 0.39±0.1 (SD) mg/day, 50% being derived from the transformation of plasma testosterone. In women the production of DHT was 0.05±0.028 (SD) mg/day, only 10% coming from testosterone. During pregnancy, the production of testosterone and dihydrotestosterone are similar to that in normal women. In three patients with testicular feminization syndrome (an adult with hyperthyroidism and two children) these two MCRs were greatly reduced compared to the normal females, but the conversion of testosterone into dihydrotestosterone was in the limits of normal male rangeIn the normal subjects the renal clearance of androstenedione was greater than that of testosterone and dihydrotestosterone. Less than 20% of the dihydrotestosterone and less than 10% of the androstenedione in the urine is derived from the plasma dihydrotestosterone and androstenedione.