Prevalence and clinical features of non-motor symptoms of essential tremor in Shanghai rural area.
Prevalence and clinical features of non-motor symptoms of essential tremor in Shanghai rural area.
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DOI：
10.1016/j.parkreldis.2015.10.617
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发表时间：
2016
影响因子：
4.1
通讯作者：
Yiwen Wu;Xi Wang;Cheng Wang;Qian Sun;Ning Song;Yi Zhou;Qian-wen Jiang;Y. Qiao;Jing Xu;L. Liang;Huidong Tang;Jianfang Ma;Xiang Gao;S. Chen
中科院分区：
文献类型：
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作者：
Yiwen Wu;Xi Wang;Cheng Wang;Qian Sun;Ning Song;Yi Zhou;Qian-wen Jiang;Y. Qiao;Jing Xu;L. Liang;Huidong Tang;Jianfang Ma;Xiang Gao;S. Chen
迄今为止，关于特发性震颤（ET）及其非运动症状（NMS）的流行病学研究很少。因此，我们进行了挨家挨户的调查，调查的ET和NMS及其临床表现在农村地区的上海，China.MethodsWe招募了19,614居民（≥50岁），生活在马陆镇，上海。调查分为两个步骤。在第一步中，受过训练的医生进行挨家挨户的调查，并向运动障碍专家报告可能的ET受试者。在第二步中，疑似ET的参与者由运动障碍专家确认他们的诊断。结果在≥50岁人群中ET的患病率为0.306%（PR = 3.06/1000）。ET组简易精神状态检查量表（MMSE）评分低于对照组（25.81 ± 4.20 vs.26.63 ± 3.14，P = 0.024）。ET组患者主诉的不安腿明显高于对照组（P< 0.05）。与此相反，我们没有观察到其他NMS ET患者和对照组之间的显着差异，包括嗅觉功能（P= 0.82），抑郁症（P= 0.94），和快速眼动睡眠行为障碍（RBD）（P= 0.71）。与健康对照组相比，ET参与者中某些NMS的患病率较高。
ObjectiveFew studies regarding the epidemiology of essential tremor (ET) and its non-motor symptoms (NMS) have been conducted to date. We thus conducted a door-to-door survey to investigate the ET and its NMS and their clinical manifestations in a rural area of Shanghai, China.MethodsWe recruited 19,614 residents (≥50 years old), living in Malu town, Shanghai. Investigations were divided into two steps. In first step, trained physicians conducted door-to-door surveys and reported probable ET subjects to movement disorder specialists. In the second step, participants with suspected ET had their diagnosis confirmed by movement disorder specialists. We randomly selected 123 subjects from those adults who screened negative for neurological conditions as healthy controls for the study of NMS.ResultsThe prevalence of ET in individuals (≥50 years old) was 0.306% (PR = 3.06 per 1000). The mini–mental state examination (MMSE) scores were lower in ET patients than in controls (25.81 ± 4.20 vs. 26.63 ± 3.14,P= 0.024). Complaints of restless legs reported by ET patients were significantly higher than those in controls (P< 0.05). In contrast, we did not observe a significant difference for other NMS between ET patients and controls, including olfactory function (P= 0.82), depression (P= 0.94), and rapid eye movement sleep behavior disorder (RBD) (P= 0.71).ConclusionsThe prevalence of ET in people≥50 years old in a rural area of Shanghai China is low. Prevalence of certain NMSs was higher among participants with ET relative to health controls.