Light-Responsive Molecular Release from Cubosomes Using Swell-Squeeze Lattice Control.
Light-Responsive Molecular Release from Cubosomes Using Swell-Squeeze Lattice Control.
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DOI：
10.1021/jacs.2c08583
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发表时间：
2022-10-26
影响因子：
15
通讯作者：
Divitini, Giorgio
中科院分区：
文献类型：
--
作者：
Evans, Rachel C.;Jones, Beatrice E.;Kelly, Elaine A.;Cowieson, Nathan;Divitini, Giorgio
刺激响应材料对于推进药物和催化剂的受控递送系统至关重要。溶致液晶（LLC）具有适合于捕获小分子的明确的内部结构，并且可以分解成低粘度分散体，有助于它们作为递送系统的应用。在这项工作中，我们展示了第一个例子的光响应立方LLC分散体，或cubosomes，使用可光开关的两亲物，使外部控制的LLC结构和随后的按需释放的截留的客体分子。将含有中性四乙二醇头部基团和偶氮苯-烷基尾部的偶氮苯光表面活性剂（AzoPS）组合（10-30重量%）到单油精-水体系中以产生LLC相。如使用小角X射线散射和低温透射电子显微镜观察到的，本体LLC的均化形成具有内部双连续原始立方相的直径约200 nm的颗粒的分散体。值得注意的是，增加AzoPS浓度会导致立方晶格的膨胀，提供了一种调整内部纳米结构的方法。在紫外线照射下，立方体内的AzoPS在几秒钟内发生异构化，从而导致立方晶格的压缩和晶格参数的降低。这种挤压机制被成功地利用，使光致变色的释放被困尼罗红客体分子从立方体结构在几分钟内。使用光控制LLC分散体的内部结构的能力，以及这对截留分子的保留的显著影响，表明这些系统可能具有下一代纳米递送的巨大潜力。
Stimuli-responsive materials are crucial to advance controlled delivery systems for drugs and catalysts. Lyotropic liquid crystals (LLCs) have well-defined internal structures suitable to entrap small molecules and can be broken up into low-viscosity dispersions, aiding their application as delivery systems. In this work, we demonstrate the first example of light-responsive cubic LLC dispersions, or cubosomes, using photoswitchable amphiphiles to enable external control over the LLC structure and subsequent on-demand release of entrapped guest molecules. Azobenzene photosurfactants (AzoPS), containing a neutral tetraethylene glycol head group and azobenzene-alkyl tail, are combined (from 10–30 wt %) into monoolein-water systems to create LLC phases. Homogenization of the bulk LLC forms dispersions of particles, ∼200 nm in diameter with internal bicontinuous primitive cubic phases, as seen using small-angle X-ray scattering and cryo-transmission electron microscopy. Notably, increasing the AzoPS concentration leads to swelling of the cubic lattice, offering a method to tune the internal nanoscale structure. Upon UV irradiation, AzoPS within the cubosomes isomerizes within seconds, which in turn leads to squeezing of the cubic lattice and a decrease in the lattice parameter. This squeeze mechanism was successfully harnessed to enable phototriggerable release of trapped Nile Red guest molecules from the cubosome structure in minutes. The ability to control the internal structure of LLC dispersions using light, and the dramatic effect this has on the retention of entrapped molecules, suggests that these systems may have huge potential for the next-generation of nanodelivery.
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DOI：
10.1039/jr9390000531
发表时间：
1939-01-01
期刊：
JOURNAL OF THE CHEMICAL SOCIETY
影响因子：
--
作者：
Hartley, GS;Le Fevre, RJW
通讯作者：
Le Fevre, RJW
DOI：
10.1002/anie.201804067
发表时间：
2019-03-04
期刊：
Angewandte Chemie (International ed. in English)
影响因子：
--
作者：
Barriga HMG;Holme MN;Stevens MM
通讯作者：
Stevens MM
影响因子：
5.4
作者：
Bulbake U;Doppalapudi S;Kommineni N;Khan W
通讯作者：
Khan W
影响因子：
8
作者：
Flak DK;Adamski V;Nowaczyk G;Szutkowski K;Synowitz M;Jurga S;Held-Feindt J
通讯作者：
Held-Feindt J
影响因子：
3.9
作者：
Borné, J;Nylander, T;Khan, A
通讯作者：
Khan, A