Regulation and coordination of nuclear envelope and nuclear pore complex assembly.
Regulation and coordination of nuclear envelope and nuclear pore complex assembly.
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DOI：
10.4161/nucl.23796
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发表时间：
2013-03
期刊：
影响因子：
--
通讯作者：
Imamoto N
中科院分区：
文献类型：
--
作者：
Clever M;Mimura Y;Funakoshi T;Imamoto N
在具有"开放式"有丝分裂的后生动物中，细胞经历涉及核膜（NE）完全解体的结构变化。在有丝分裂后，分裂的细胞面临着以高度调节的方式围绕分离的染色体重组NE结构的困难。核孔复合物（nuclear pore complex，NPC）是细胞质和核质之间穿过核膜的通道，其从头形成是大分子组装的原型，因此特别令人感兴趣。功能性NE的重组进一步涉及有丝分裂晚期染色体周围其他NE成分（核膜和NE蛋白）的重新组装和组织。 在这里，我们讨论NE组件，如核纤层蛋白和INM蛋白，在NE改造的功能，并强调最近的结果，NPC和NE组装的协调。
In metazoans with “open” mitosis, cells undergo structural changes involving the complete disassembly of the nuclear envelope (NE). In post-mitosis, the dividing cell faces the difficulty to reassemble NE structures in a highly regulated fashion around separated chromosomes. The de novo formation of nuclear pore complexes (NPCs), which are gateways between the cytoplasm and nucleoplasm across the nuclear membrane, is an archetype of macromolecular assembly and is therefore of special interest. The reformation of a functional NE further involves the reassembly and organization of other NE components, the nuclear membrane and NE proteins, around chromosomes in late mitosis. Here, we discuss the function of NE components, such as lamins and INM proteins, in NE reformation and highlight recent results on coordination of NPC and NE assembly.