DNA Damage and Repair Biomarkers of Immunotherapy Response.
DNA Damage and Repair Biomarkers of Immunotherapy Response.
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DOI：
10.1158/2159-8290.cd-17-0226
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发表时间：
2017-07
期刊：
影响因子：
28.2
通讯作者：
D'Andrea AD
中科院分区：
文献类型：
--
作者：
Mouw KW;Goldberg MS;Konstantinopoulos PA;D'Andrea AD
DNA损伤剂广泛应用于临床肿瘤学中，并利用肿瘤DNA修复的缺陷。鉴于免疫检查点阻断作为一种治疗策略的作用日益扩大，肿瘤DNA损伤与免疫系统的相互作用近来成为关注焦点，并且现在很清楚的是，肿瘤DNA修复情况在驱动对免疫检查点阻断的反应中具有重要作用。在此，我们总结了已发现的DNA损伤和基因组不稳定性塑造抗肿瘤免疫反应的机制，并描述了利用DNA修复生物标志物来指导免疫导向疗法使用的临床尝试。
DNA damaging agents are widely used in clinical oncology and exploit deficiencies in tumor DNA repair. Given the expanding role of immune checkpoint blockade as a therapeutic strategy, the interaction of tumor DNA damage with the immune system has recently come into focus, and it is now clear that the tumor DNA repair landscape has an important role in driving response to immune checkpoint blockade. Here, we summarize the mechanisms by which DNA damage and genomic instability have been found to shape the anti-tumor immune response and describe clinical efforts to use DNA repair biomarkers to guide use of immune-directed therapies.