A distinct role for B1b lymphocytes in T cell-independent immunity.
A distinct role for B1b lymphocytes in T cell-independent immunity.
复制标题
B1b 淋巴细胞在 T 细胞非依赖性免疫中发挥独特作用。
DOI：
10.1007/978-3-540-73900-5_5
复制
发表时间：
2008
影响因子：
--
通讯作者：
Alugupalli,KR
中科院分区：
文献类型：
--
作者：
Alugupalli,KR
Pathogenesis of infectious disease is not only determined by the virulence of the microbe but also by the immune status of the host. Vaccination is the most effective means to control infectious diseases. A hallmark of the adaptive immune system is the generation of B cell memory, which provides a long-lasting protective antibody response that is central to the concept of vaccination. Recent studies revealed a distinct function for B1b lymphocytes, a minor subset of mature B cells that closely resembles that of memory B cells in a number of aspects. In contrast to the development of conventional B cell memory, which requires the formation of germinal centers and T cells, the development of B1b cell-mediated long-lasting antibody responses occurs independent of T cell help. T cell-independent (TI) antigens are important virulence factors expressed by a number of bacterial pathogens, including those associated with biological
