EHD proteins: key conductors of endocytic transport.

EHD proteins: key conductors of endocytic transport.
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DOI:
10.1016/j.tcb.2010.10.003
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发表时间:
2011-02
影响因子:
19
通讯作者:
Caplan, Steve
Caplan, Steve
中科院分区:
生物学1区
文献类型:
--
作者:
Naslavsky, Naava;Caplan, Steve

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Regulation of endocytic transport is controlled by an elaborate network of proteins. Rab GTP-binding proteins and their effectors have well-defined roles in mediating specific endocytic transport steps, but until recently, less was known about the four mammalian dynamin-like C-terminal Eps15 Homology Domain (EHD) proteins that also regulate endocytic events. In recent years, however, great strides have been made in understanding the structure and function of these unique proteins. Indeed, a growing body of literature addresses EHD protein structure, interactions with binding partners, functions in mammalian cells, and the generation of various new model systems. Accordingly, this is now an opportune time to pause and review the function and mechanisms of action of EHD proteins, and to highlight some of the challenges and future directions for the field.
哺乳动物细胞和秀丽隐杆线虫中的生化和功能比较揭示了EHD蛋白的共享和不同作用。
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