The Genetic Contribution of West-African Ancestry to Protection against Central Obesity in African-American Men but Not Women: Results from the ARIC and MESA Studies.
The Genetic Contribution of West-African Ancestry to Protection against Central Obesity in African-American Men but Not Women: Results from the ARIC and MESA Studies.
复制标题
西非血统对保护非裔美国人而不是女性的中枢性肥胖的遗传贡献：ARIC和MESA研究的结果。
DOI：
10.3389/fgene.2016.00089
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发表时间：
2016
影响因子：
3.7
通讯作者：
Allison DB
中科院分区：
文献类型：
--
作者：
Klimentidis YC;Arora A;Zhou J;Kittles R;Allison DB
超过 80% 的非裔美国 (AA) 女性超重或肥胖。 AA 和欧洲裔美国人 (EA) 之间的肥胖率在女性中存在巨大的种族差异，但奇怪的是在男性中却没有。尽管社会经济和/或文化因素可能部分解释了这种种族与性别之间的相互作用，但遗传因素的潜在参与尚未得到研究。在社区动脉粥样硬化风险研究中的 2814 名自我认定的 AA 中，我们使用 3437 个祖先信息标记估计了每个人的西非遗传祖先程度。然后，我们测试了性别是否改变了西非遗传血统与体重指数（BMI）、腰围（WC）和腰臀比（WHR）之间的关联，调整了收入和教育水平，并分别检查了男性和女性的血统与表型的关联。我们在动脉粥样硬化多种族研究 (n = 1611 AA) 中重复了我们的发现。在这两项研究中，我们发现，在 AA 男性中，西非血统与肥胖（尤其是向心性肥胖）呈负相关，但在 AA 女性中则不然（在 WHR 汇总分析中，pinteraction = 4.14 × 10−5）。总之，我们的研究结果表明，男性性别和西非遗传血统的结合与预防中心性肥胖有关，并表明女性而非男性之间存在的巨大种族差异可能至少部分归因于遗传因素。
Over 80% of African-American (AA) women are overweight or obese. A large racial disparity between AA and European-Americans (EA) in obesity rates exists among women, but curiously not among men. Although socio-economic and/or cultural factors may partly account for this race-by-sex interaction, the potential involvement of genetic factors has not yet been investigated. Among 2814 self-identified AA in the Atherosclerosis Risk in Communities study, we estimated each individual's degree of West-African genetic ancestry using 3437 ancestry informative markers. We then tested whether sex modifies the association between West-African genetic ancestry and body mass index (BMI), waist-circumference (WC), and waist-to-hip ratio (WHR), adjusting for income and education levels, and examined associations of ancestry with the phenotypes separately in males and females. We replicated our findings in the Multi-Ethnic Study of Atherosclerosis (n = 1611 AA). In both studies, we find that West-African ancestry is negatively associated with obesity, especially central obesity, among AA men, but not among AA women (pinteraction = 4.14 × 10−5 in pooled analysis of WHR). In conclusion, our results suggest that the combination of male gender and West-African genetic ancestry is associated with protection against central adiposity, and suggest that the large racial disparity that exists among women, but not men, may be at least partly attributed to genetic factors.