Differential expression of estrogen-related receptors β and γ (ERRβ and ERRγ) and their clinical significance in human prostate cancer
Differential expression of estrogen-related receptors β and γ (ERRβ and ERRγ) and their clinical significance in human prostate cancer
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DOI：
10.1111/j.1349-7006.2009.01451.x
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发表时间：
2010-03-01
期刊：
影响因子：
5.7
通讯作者：
Inoue, Satoshi
中科院分区：
文献类型：
--
作者：
Fujimura, Tetsuya;Takahashi, Satoru;Inoue, Satoshi
雌激素相关受体（ERR）是调节雌激素信号通路的核受体。在这里，我们研究了ERR β和ERR γ在人前列腺组织中的表达。使用原始的兔多克隆抗ERR β和抗ERR γ抗体，通过对通过根治性乳腺癌切除术获得的癌性病变（n = 107）和良性病灶（n = 92）的免疫组织化学分析来评估ERR β和ERR γ的表达。评价染色玻片的免疫反应性细胞比例及其染色强度。总免疫反应性评分（IR评分;范围，0-8）计算为比例和强度评分之和。评估患者的临床病理学特征与三种ERR（ERR α、ERR β和ERR γ）表达之间的关系。癌性病灶ERR β和ERR γ的IR评分显著低于良性病灶（P < 0.0001）。临床病理分析显示，ERR γ IR评分低的患者（
Estrogen-related receptor (ERR) is a nuclear receptor that modulates the estrogen-signaling pathway. Here, we investigated the expression of both ERR beta and ERR gamma in human prostate tissues. Using original rabbit polyclonal anti-ERR beta and anti-ERR gamma antibodies, the expression of ERR beta and ERR gamma was evaluated by immunohistochemical analysis of cancerous lesions (n = 107) and benign foci (n = 92), obtained by radical prostatectomy. Stained slides were evaluated for the proportion of immunoreactive cells and their staining intensity. Total immunoreactivity scores (IR scores; range, 0-8) were calculated as the sum of the proportion and intensity scores. The relationship between the clinicopathological characteristics of the patients and the expression of the three ERRs (ERR alpha, ERR beta, and ERR gamma) was evaluated. IR scores for ERR beta and ERR gamma were significantly lower in cancerous lesions than that in benign foci (P < 0.0001, for both). Clinicopathological analyses revealed that the patients with low ERR gamma IR scores (