Evidence that reversed glutamate uptake contributes significantly to glutamate release following experimental injury to the rat spinal cord
Evidence that reversed glutamate uptake contributes significantly to glutamate release following experimental injury to the rat spinal cord
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DOI：
10.1016/s0006-8993(00)02296-4
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发表时间：
2000-05-26
期刊：
影响因子：
2.9
通讯作者：
Price, EM
中科院分区：
文献类型：
--
作者：
McAdoo, DJ;Xu, GY;Price, EM
释放的兴奋性氨基酸在脊髓损伤后的继发性损伤中起重要作用。由于细胞膜去极化导致的正常转运的抑制可能有助于这种释放。我们通过微透析法将二氢红藻氨酸（DHK）（一种非转运的谷氨酸摄取阻滞剂）注入大鼠脊髓，与挫伤性脊髓损伤相关。损伤后谷氨酸的释放减少了34%（P
Released excitatory amino acids contribute significantly to secondary damage following spinal cord injury. Reversal of normal transport due to cell membrane depolarization may contribute to this release. We tested this by administering dihydrokainic acid (DHK), a non-transported glutamate uptake blocker, into the rat spinal cord by microdialysis in association with contusion spinal cord injury. Glutamate release in response to injury was reduced by 34% (P