Local cerebral blood flow, local cerebral glucose utilization, and flow -: Metabolism coupling during sevoflurane versus isoflurane anesthesia in rats
Local cerebral blood flow, local cerebral glucose utilization, and flow -: Metabolism coupling during sevoflurane versus isoflurane anesthesia in rats
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DOI：
10.1097/00000542-199812000-00026
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发表时间：
1998-12-01
期刊：
影响因子：
8.8
通讯作者：
Waschke, KF
中科院分区：
文献类型：
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作者：
Lenz, C;Rebel, A;Waschke, KF
与异氟醚相比，七氟醚麻醉期间对局部脑葡萄糖利用率（LCGU）和局部脑血流量（LCBF）的了解有限。方法：采用放射自显像2-[C-14]脱氧- d -葡萄糖和4-碘- n -甲基[C-14]安替吡林方法，在Sprague-Dan ley大鼠（8组，每组n = 6）和清醒对照动物（2组，每组n = 6）中测量七氟醚和异氟醚麻醉期间的LCGU、LCBF及其总体均值。结果：麻醉期间平均脑葡萄糖利用率降低：对照组56 +/- 5 μ mol 100 g(-1) min(-1)；1 MAC异氟烷，32 +/- 4 μ mol 100 g(-1) min(-1) (-43%)；1 MAC七氟醚，37 +/- 5 μ mol 100 g(-1) min(-1) (-34%)；2 MAC异氟烷，23 +/- 3 μ mol, 100 g(-1)min(-1) (- 58%)；2 MAC七氟醚，23 +/- 5 μ mol 100 g(-1) min(-1)（-59%）。局部分析显示，在被分析的40个脑区中，LCGU的大部分都有所减少。平均脑血流量增加如下：对照组93 +/- 8 mi 100 g(-1) min(-1)；1 MAC异氟醚，119 +/- 19 ml 100 g(-1) min(-1) (+28%)；1 MAC七氟醚，104 +/- 15 ml 100 g(-1) min(-1)(+12%)；2 MAC异氟醚，149 +/- 17ml 100 g(-1) min(-1) (+60%)；2 MAC七氟醚，118 +/- 21 mi 100 g(-1) min(-1)（+27%）。LCBF tva在大多数被调查的大脑结构中增加。LCGU与LCBF的相关系数为：对照0.93；1 MAC异氟烷，0.89；2 MAC异氟烷，0.71；1 MAC七氟烷，0.83；2 MAC七氟醚，0.59)。结论：七氟醚麻醉时平均脑血流量和局部脑血流量均低于异氟醚麻醉。这种差异不能用葡萄糖利用的不同变化来解释，因为两组中葡萄糖利用的下降程度相同。
Background Compared to isoflurane, knowledge of local cerebral glucose utilization (LCGU) and local cerebral blood flow (LCBF) during sevoflurane anesthesia is limited,Methods: LCGU, LCBF, and their overall means were measured in Sprague-Dan ley rats (8 groups, n = 6 each) during sevoflurane and isoflurane anesthesia, 1 and 2 MAC, and in conscious control animals (2 groups, n = 6 each) using the autoradiographic 2-[C-14]deoxy-D-glucose and 4-iodo-N-methyl[C-14]antipyrinc methods. Results: During anesthesia mean cerebral glucose utilization was decreased:control 56 +/- 5 mu mol 100 g(-1) min(-1); 1 MAC isoflurane, 32 +/- 4 mu mol 100 g(-1) min(-1) (-43%); 1 MAC sevoflurane, 37 +/- 5 mu mol 100 g(-1) min(-1) (-34%); 2 MAC isoflurane, 23 +/- 3 mu mol. 100 g(-1)min(-1) (- 58%); 2 MAC sevoflurane, 23 +/- 5 mu mol 100 g(-1) min(-1) (-59%). Local analysis showed a reduction In LCGU in the majority of the 40 brain regions analyzed. Mean cerebral blood flow was increased as follows: control 93 +/- 8 mi 100 g(-1) min(-1); 1 MAC isoflurane, 119 +/- 19 ml 100 g(-1) min(-1) (+28%); 1 MAC sevoflurane, 104 +/- 15 ml 100 g(-1) min(-1)(+12%); 2 MAC isoflurane, 149 +/- 17ml 100 g(-1) min(-1) (+60%); 2 MAC sevoflurane, 118 +/- 21 mi 100 g(-1) min(-1) (+27%). LCBF Tvas increased in most brain structures investigated. Correlation coefficients obtained for the relationship between LCGU and LCBF were as follows: control 0.93; 1 MAC isoflurane, 0.89; 2 MAC isoflurane, 0.71; 1 MAC sevoflurane, 0.83; 2 MAC sevoflurane, 0.59).Conclusion: Mean and local cerebral blood flows were lower during sevoflurane than during Isoflurane anesthesia. This difference cannot be explained by differing changes in glucose utilization because glucose utilization was decreased to the same extent in both groups.