Platelet-activating factor receptor affects food intake and body weight.
Platelet-activating factor receptor affects food intake and body weight.
复制标题
血小板激活因子受体会影响食物摄入和体重。
DOI：
10.1016/j.gendis.2015.06.002
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发表时间：
2015-09
期刊：
影响因子：
6.8
通讯作者：
McIntyre TM
中科院分区：
文献类型：
--
作者：
Li W;McIntyre TM
“让我们动起来！”是由第一夫人米歇尔·奥巴马发起的一项综合性倡议，致力于解决儿童中日益严重的肥胖问题。生活行为确实会影响肥胖；然而，在分子水平上的机理尚不清楚。在这项研究中，通过持续监测小鼠在高脂西方饮食下的体重，以及在CLAMS综合实验动物监测系统中评估的代谢，身体活动和食物摄入行为，我们证明了血小板活化因子受体（PTAFR）有助于改变生活行为。PTAFR不影响幼龄动物摄入的膳食脂肪和碳水化合物的代谢；然而，Ptafr消融在不影响脂肪组织积累的情况下显著增加体重。Ptafr - / -小鼠具有增加食物摄入量和减少运动的新习惯。我们的研究表明，调节PTAFR活性可能是控制儿童或年轻人肥胖的一种新策略。
“Let's Move!” is a comprehensive initiative, launched by the First Lady, Michelle Obama, dedicates to solving problems of obesity, which is growing in child. The life behaviors do affect obesity; however, the mechanistic insight in molecular level is still not clear. In this study, by continually monitoring mouse body weight under chow and high fat western diets as well as metabolic, physical activity and food intake behaviors assessed in a CLAMS Comprehensive Lab Animal Monitoring System, we demonstrated that the platelet-activating factor receptor (PTAFR) contributes to modification of life behaviors. PTAFR does not affect metabolism of ingested dietary fat and carbohydrate in young animals; however, Ptafr ablation dramatically increased weight gain without affecting adipose tissue accumulation. Ptafr−/− mice possess new habits that increased food intake and decreased movement. Our studies suggest that regulation of PTAFR activity may be a novel strategy to control obesity in children or young adults.