MILK DIET PARA-AMINOBENZOIC ACID, AND MALARIA (P-BERGHEI) - PRELIMINARY COMMUNICATION
MILK DIET PARA-AMINOBENZOIC ACID, AND MALARIA (P-BERGHEI) - PRELIMINARY COMMUNICATION
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DOI：
10.1136/bmj.1.4821.1201
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发表时间：
1953-01-01
影响因子：
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通讯作者：
HAWKING, F
中科院分区：
文献类型：
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作者：
HAWKING, F
我们在四只实验猴身上观察到了牛奶饮食的抑制作用。这与magraith等人在大鼠伯氏杆菌感染中的记录没有什么不同。没有一种动物的抑制是完全的，但是（除了一种情况是暂时的）寄生虫血症处于较低水平，并且所有四种感染都与正常饮食的猴子的感染完全不同。孢子虫引起的感染与血液引起的感染行为基本相同；然而，在126只接受了更大剂量孢子虫的猴子中，突破发生在接种后的第10天和第11天，当时血液中充满了幼环；然后，寄生虫的密度没有增加，反而下降到可以忽略不计的水平。该动物的肝脏活检显示有许多形态正常的红细胞前分裂。它们明显地成熟了，破裂了，它们的产品进入了循环，没有受到“牛奶因子”的伤害。换句话说，后者既不作用于红细胞前分裂体，也不作用于游离的分裂子，人们认为，不良影响一定是在未成熟的血分裂体上——可能在核分裂活跃阶段，脱氧核糖核酸变得必不可少（Bray和Garnham， 1953）——事实上，第11天看到的这种分裂体比正常分裂体小，形状不规则。结果表明，“乳因子”对配子体发育无影响。牛奶饮食足以防止脾切除术后的突破（见猴子M 121）；但在恢复正常饮食的几天内，严重的复发发生了。一旦停止牛奶饮食，同源菌株的重复感染也有同样的效果。在没有干扰的情况下（如孢子虫引起的感染），恢复正常饮食后，感染程度略有升高。这些结果表明，在这些动物暴露于低寄生虫率的时间里，也就是说，在四周的时间里，很少或没有产生疫苗。
Discussion The suppressive effect of a milk diet was observed in our four experimental monkeys. It was not unlike that recorded by Maegraith et al. in P. berghei infections in rats. In no animals was suppression complete, but (except temporarily in one instance) parasitaemia was at a low level, and all four infections were quite different from those seen in monkeys on a normal diet. Sporozoite-induced infections behaved much the same as blood-induced infections; however, in monkey 126, which had received the heavier dose of sporozoites, a break-through occurred on the tenth and eleventh days after inoculation, when the blood became flooded with young rings; the density of parasites did not then increase, but on the contrary dropped to a negligible level. The liver biopsy of this animal had revealed numerous pre-erythrocytic schizonts of normal morphology. These apparently reached maturity, ruptured, and their products entered the circulation unharmed by the" milk factor." In other words the latter acted neither on the pre-erythrocytic schizont nor on the free merozoite, and it is thought that the adverse effect must be upon the im-mature blood schizont-probably at the stage of active nuclear division when desoxyribonucleic'acid becomes essential (Bray and Garnham, 1953)-in fact such schizonts seen on the eleventhday were smaller than normal and irregular in formation. The observation that sporogony in the mosquito followed the normal course indicated that the" milk factor" was unable to harm the gametocyte stage.A milk diet was powerful enough to prevent a break-through after splenectomy (see monkey M 121); but within a few days of returnto a normaldiet a severe recrudescence took place. Superinfection with a homologous strain had the same effect once the milk diet had been stopped. With no interference (as in thesporozoite-induced infections) the infections became slightly heightened after return to a normal diet. These results suggest that little or no premunition developed during the time that the animals had been exposed to a low parasitaemia-that is, for four weeks.