Inflammatory markers at the site of ruptured plaque in acute myocardial infarction -: Locally increased interleukin-6 and serum amyloid A but decreased C-reactive protein
Inflammatory markers at the site of ruptured plaque in acute myocardial infarction -: Locally increased interleukin-6 and serum amyloid A but decreased C-reactive protein
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DOI：
10.1161/01.cir.0000158479.58589.0a
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发表时间：
2005-03-22
期刊：
影响因子：
37.8
通讯作者：
Lüscher, TF
中科院分区：
文献类型：
--
作者：
Maier, W;Altwegg, LA;Lüscher, TF
背景——急性心肌梗死（AMI）与炎症有关。然而，尚不清楚它是来自破裂的斑块还是代表一个系统性的过程。方法与结果：42例AMI患者在急性冠状动脉介入治疗中采用球囊栓塞保护装置和穿刺导管（PercuSurge）。在远端球囊闭塞下从破裂斑块的部位采集样本。从主动脉采集全身样本。分析血清、斑块和血栓的炎症标志物和脂蛋白。主动脉c反应蛋白（CRP）、白细胞介素-6 （IL-6）和血清淀粉样蛋白A （SAA）的全身水平分别为3.0 mg/L、5.0 ng/L和22.1 mg/L（四分位数范围[IQRs]，分别为1.1 ~ 7.4 mg/L、5.0 ~ 6.5 ng/L和13.9 ~ 27.0 mg/L）。在破裂斑块周围的血液中，局部IL-6水平（8.9 ng/L； IQR, 5.0 ~ 16.9 ng/L）和SAA水平（24.3 mg/L； IQR, 16.3 ~ 44.0 mg/L）明显高于主动脉，而CRP水平（2.5 mg/L； IQR, 0.9 ~ 7.7 mg/L）较主动脉降低（P < 0.05）
Background-Acute myocardial infarction (AMI) is associated with inflammation. However, it remains unclear whether it originates from the ruptured plaque or represents a systemic process.Methods and Results-In 42 patients with AMI, a balloon-based embolization protection device and aspiration catheter (PercuSurge) were used during acute coronary interventions. Samples from the site of the ruptured plaque were taken under distal balloon occlusion. Systemic samples were taken from the aorta. Sera, plaques, and thrombi were analyzed for inflammatory markers and lipoproteins. Systemic levels of C-reactive protein (CRP), interleukin-6 (IL-6), and serum amyloid A (SAA) in the aorta amounted to 3.0 mg/L, 5.0 ng/L, and 22.1 mg/L, respectively (interquartile ranges [IQRs], 1.1 to 7.4 mg/L, 5.0 to 6.5 ng/L, and 13.9 to 27.0 mg/L, respectively). In blood surrounding ruptured plaques, local levels of IL-6 (8.9 ng/L; IQR, 5.0 to 16.9 ng/L) and SAA (24.3 mg/ L; IQR, 16.3 to 44.0 mg/ L) were significantly higher, whereas CRP levels (2.5 mg/L; IQR, 0.9 to 7.7 mg/L) were decreased compared with the aorta (all P