Somatostatin receptor expression in Merkel cell carcinoma as target for molecular imaging
Somatostatin receptor expression in Merkel cell carcinoma as target for molecular imaging
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DOI：
10.1186/1471-2407-14-268
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发表时间：
2014-04-17
期刊：
影响因子：
3.8
通讯作者：
Becker, Jurgen C.
中科院分区：
文献类型：
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作者：
Buder, Kristina;Lapa, Constantin;Becker, Jurgen C.
背景：默克尔细胞癌（MCC）是一种罕见的皮肤肿瘤，其发病率不断增加，具有侵袭性和预后不良。生长抑素受体 (SSTR) 在 MCC 中表达，是成像和治疗的潜在靶点。方法：使用 PET 和放射性示踪剂 [Ga-68] DOTA-D-Phe(1)Tyr(3)-奥曲肽 (DOTATOC) 或 -奥曲肽 (DOTATATE) 作为肿瘤负荷的替代物，无创评估 MCC 中 SSTR 的表达。对 24 名经组织学证实的 MCC 患者进行了 SSTR-PET，并与计算机断层扫描 (CT) 结果进行比较。结果：SSTR-PET 检测到原发性和转移性 MCC 病变。在基于患者的分析中，SSTR-PET 对淋巴结转移、骨转移和软组织转移的敏感性分别为 73%、100% 和 67%。值得注意的是，2 名患者最初通过 SSTR-PET 检测到脑转移，而肝和肺转移仅通过 CT 诊断。 24 名患者中有 20 名 SSTR-PET 显示与 CT 结果一致。 4 名患者 (17%) 由于 SSTR-PET 导致分期上调，3 名患者 (13%) 的患者管理发生改变。 结论：SSTR-PET 对骨、软组织和脑转移成像显示出高敏感性，特别是与 CT 结合使用对临床分期和患者管理具有显着影响。
Background: Merkel cell carcinoma (MCC) is a rare cutaneous neoplasm with increasing incidence, aggressive behavior and poor prognosis. Somatostatin receptors (SSTR) are expressed in MCC and represent a potential target for both imaging and treatment.Methods: To non-invasively assess SSTR expression in MCC using PET and the radiotracers [Ga-68] DOTA-D-Phe(1)Tyr(3)- octreotide (DOTATOC) or -octreotate (DOTATATE) as surrogate for tumor burden. In 24 patients with histologically proven MCC SSTR-PET was performed and compared to results of computed tomography (CT).Results: SSTR-PET detected primary and metastatic MCC lesions. On a patient-based analysis, sensitivity of SSTR-PET was 73% for nodal metastases, 100% for bone, and 67% for soft-tissue metastases, respectively. Notably, brain metastases were initially detected by SSTR-PET in 2 patients, whereas liver and lung metastases were diagnosed exclusively by CT. SSTR-PET showed concordance to CT results in 20 out of 24 patients. Four patients (17%) were up-staged due to SSTR-PET and patient management was changed in 3 patients (13%).Conclusion: SSTR-PET showed high sensitivity for imaging bone, soft tissue and brain metastases, and particularly in combination with CT had a significant impact on clinical stage and patient management.