LOCALIZATION AND MOLECULAR HETEROGENEITY OF CHOLECYSTOKININ IN THE CENTRAL AND PERIPHERAL NERVOUS-SYSTEM
LOCALIZATION AND MOLECULAR HETEROGENEITY OF CHOLECYSTOKININ IN THE CENTRAL AND PERIPHERAL NERVOUS-SYSTEM
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DOI：
10.1016/0006-8993(79)90554-7
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发表时间：
1979-01-01
期刊：
影响因子：
2.9
通讯作者：
REHFELD, JF
中科院分区：
文献类型：
--
作者：
LARSSON, LI;REHFELD, JF
免疫细胞化学和放射免疫化学证实豚鼠中枢和外周神经系统中都存在胃肠激素胆囊收缩素（CCK）。CCK神经在新皮质、海马、杏仁核、下丘脑、脊髓和结肠中特别多。神经含有CCK的5种分子组分，凝胶色谱洗脱常数（Kav）分别为0.05、0.50、0.90、1.10和1.30。后者4分别对应于三肽CCK及其COOH末端十二肽、八肽和四肽部分。胆固醇缩血管肽广泛分布于神经系统中，并以相当大的量（≥ 1000）存在。0.2 nmol CCK-8当量/（三）在不同的地区。
Immunocytochemistry and radioimmunochemistry demonstrate the occurrence of the gastrointestinal hormone cholecystokinin (CCK) in both the central and peripheral nervous system of the guinea pig. CCK nerves are particularly numerous in the neocortex, the hippocampus, the amygdaloid nuclei, the hypothalamus, the spinal cord and in the colon. The nerves contain 5 molecular components of CCK, with gel chromatographical elution constants (Kav) of 0.05, 0.50, 0.90, 1.10 and 1.30, respectively. The 4 latter correspond to triacontatripeptide CCK and its COOH-terminal dodeca-, octa- and tetrapeptide portions, respectively. Cholecystokinins are widely distributed in the nervous system and occur in substantial quantities (.gtoreq. 0.2 nmol CCK-8-equiv./g) in several distinct regions.