Shrunken Pore Syndrome Is Associated With Increased Levels of Atherosclerosis-Promoting Proteins
Shrunken Pore Syndrome Is Associated With Increased Levels of Atherosclerosis-Promoting Proteins
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DOI：
10.1016/j.ekir.2018.09.002
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发表时间：
2019-01-01
影响因子：
6
通讯作者：
Grubb, Anders
中科院分区：
文献类型：
--
作者：
Almen, Markus Sallman;Bjork, Jonas;Grubb, Anders
简介：缩孔综合征（SPS）最初定义为基于胱抑素C的估计肾小球滤过率（eGFR（胱抑素C））小于基于肌酐的估计肾小球滤过率（eGFR（肌酐））的60%，且不存在对胱抑素C或肌酐血浆水平的肾外影响，即使在不存在肾小球滤过率（GFR）降低的情况下，SPS也与死亡率的高增加相关。本研究的目的是确定SPS患者的蛋白质组是否显示出与正常或降低测量GFR（mGFR）无SPS的患者的差异。方法：包括四个患者队列：1队列与正常mGFR无SPS，1与正常mGFR与SPS，1与降低mGFR无SPS，1与降低mGFR与SPS。结果：30种蛋白质的血浆水平差异是SPS特异性的; 31种蛋白质的差异是SPS和mGFR降低患者特异性的; 27种蛋白质的差异是mGFR降低患者特异性的。18个SPS特异性差异涉及被描述为促进动脉粥样硬化或与动脉粥样硬化相关的蛋白质。对于SPS和mGFR降低的患者，12个特异性差异和10个特异性差异也涉及被描述为促进动脉粥样硬化或与动脉粥样硬化相关的蛋白质。几乎所有浓度差异（82/88）均表示浓度升高。对于SPS，但不是减少mGFR，蛋白质大小和水平的增加之间的相关性进行了观察，与较小的蛋白质与较高的levels.Conclusion：在收缩毛孔综合征的高死亡率可能是由动脉粥样硬化促进蛋白在这种情况下的积累。
Introduction: Shrunken pore syndrome (SPS), originally defined by cystatin C-based estimated glomerular filtration rate (eGFR(cystatin C)) being less than 60% of creatinine-based estimated glomerular filtration rate (eGFR(creatinine)) in the absence of extrarenal influences on the plasma levels of cystatin C or creatinine, is associated with a high increase in mortality, even in the absence of reduced glomerular filtration rate (GFR). The objective of the present study was to determine whether the proteome of patients with SPS shows differences from that of patients with normal or reduced measured GFR (mGFR) without SPS.Methods: Four patient cohorts were included: 1 cohort with normal mGFR without SPS, 1 with normal mGFR with SPS, 1 with reduced mGFR without SPS, and 1 with reduced mGFR with SPS. The plasma levels of 177 selected proteins were analyzed.Results: Differences in the levels of 30 proteins were specific for SPS; 31 differences were specific for patients with both SPS and reduced mGFR; and 27 were specific for reduced mGFR. Eighteen of the differences specific for SPS concerned proteins described as promoting, or being associated with, atherosclerosis. Twelve of the differences specific for patients with both SPS and reduced mGFR and 10 of the differences specific for reduced mGFR also concerned proteins described as promoting, or being associated with, atherosclerosis. Almost all (82 of 88) of the concentration differences represented increased levels. For SPS, but not for reduced mGFR, a correlation between protein size and increase in level was observed, with smaller proteins being associated with higher levels.Conclusion: The high mortality in shrunken pore syndrome might be caused by the accumulation of atherosclerosis-promoting proteins in this condition.