Physicochemical properties and biocompatibility of chitosan oligosaccharide/gelatin/calcium phosphate hybrid cements
Physicochemical properties and biocompatibility of chitosan oligosaccharide/gelatin/calcium phosphate hybrid cements
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DOI：
10.1016/j.matchemphys.2009.11.007
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发表时间：
2010-04-15
影响因子：
4.6
通讯作者：
Ding, Shinn-Jyh
中科院分区：
文献类型：
--
作者：
Chiang, Ting-Yi;Ho, Chia-Che;Ding, Shinn-Jyh
研制了一种由壳寡糖（COS）溶液和明胶（GLT）磷酸钙粉末组成的骨替代材料。评价了复合骨水泥的理化性能和生物相容性。COS的加入并不影响混合水泥的凝固时间或径向抗拉强度，而GLT显着延长凝固时间和强度略有下降。在初始混合物中加入GLT可抑制凝固反应，但COS不抑制凝固反应。然而，与COS相比，GLT的存在明显改善了混合水泥的抗冲刷性能。COS可以促进骨水泥的生物相容性，因为与对照组相比，在第3天观察到含10%COS的骨水泥的细胞增殖增加约两倍。选择GLT和COS的组合是因为从几种协同效应中获得的益处及其临床应用。从抗冲刷性能和生物活性方面考虑，5%GLT和10%COS的水泥可能是较好的选择。皇冠版权所有（c）2009年出版的爱思唯尔B.V.保留所有权利。
A bone substitute material was developed consisting of a chitosan oligosaccharide (COS) solution in a liquid phase and gelatin (GLT) containing calcium phosphate powder in a solid phase. The physicochemical and biocompatible properties of the hybrid cements were evaluated. The addition of COS to cement did not affect the setting time or diametral tensile strength of the hybrid cements, whereas GLT significantly prolonged the setting time and decreased the strength slightly. The setting reaction was inhibited by the addition of GLT to the initial mixture, but not by COS. However, the presence of GLT appreciably improved the anti-washout properties of the hybrid cement compared with COS. COS may promote the cement's biocompatibility as an approximate twofold increase in cell proliferation for 10% COS-containing cements was observed on day 3 as compared with the controls. The combination of GLT and COS was chosen due to the benefits achieved from several synergistic effects and for their clinical applications. Cement with 5% GLT and 10% COS may be a better choice among cements in terms of anti-washout properties and biological activity. Crown Copyright (c) 2009 Published by Elsevier B.V. All rights reserved.