Glycine in the lizard retina: comparison to the GABA system.
Glycine in the lizard retina: comparison to the GABA system.
复制标题
蜥蜴视网膜中的甘氨酸：与 GABA 系统的比较。
DOI：
10.1017/s0952523800005393
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发表时间：
1993
影响因子：
1.9
通讯作者：
Yazulla,S
中科院分区：
文献类型：
--
作者：
Sherry,DM;Micich,A;Yazulla,S
用免疫细胞化学方法鉴定了全锥蜥蜴视网膜中可能利用甘氨酸（GLY）作为神经递质的神经元，并比较了视网膜GLY和γ -氨基丁酸（GABA）系统的基本解剖结构。鉴定出四种gly -免疫反应（GLY-IR）神经元。GLY-IR细胞多为无增生性细胞，至少包括两种类型。GLY-IR丛状细胞和神经节细胞也被鉴定出来。第一种GLY-IR无突细胞类型的特征是位于内丛状层（IPL）边缘远端的梨状小体和细树突。大多数GLY-IR无毛细胞属于这种类型，在这一组中可能存在几种亚型。第二种无毛细胞类型的特征是一个大的、位于远端的体细胞和一个大的下降过程。这种无毛细胞类型显示GLY-IR和GABA-IR共定位，约占GLY-IR无毛细胞总数的4%。GLY- ir和GABA- ir序列切片的比较表明，GLY和GABA在很大程度上存在于不同的神经元群体中。与GABA-IR无突细胞相比，GLY-IR无突细胞体积更小，位于内核层更远端，树突更细。GLY-IR和GABA-IR在网状外层和网状内层的分布差异较大。基于GLY- ir和GABA- ir在蜥蜴视网膜突触层的分离分布，GLY和GABA可能在视网膜加工中具有根本不同的作用。
Neurons likely to utilize glycine (GLY) as a neurotransmitter were identified immunocytochemically in the “all-cone” lizard retina and the basic anatomical organization of the retinal GLY and gamma-aminobutyric acid (GABA) systems was compared. Four types of GLY-immunoreactive (GLY-IR) neurons were identified. Most GLY-IR cells were amacrine cells, which comprised at least two types. GLY-IR interplexiform cells and ganglion cells also were identified. The first GLY-IR amacrine cell type was characterized by a small pyriform soma, located distal to the border of the inner plexiform layer (IPL), and fine dendrites. Most GLY-IR amacrine cells were of this type and several subtypes may exist within this group. The second amacrine cell type was characterized by a large, distally located soma and a large descending process. This amacrine cell type showed colocalization of GLY-IR and GABA-IR and comprised about 4% of the total GLY-IR amacrine cell population.Comparison of GLY-IR and GABA-IR on serial sections showed that GLY and GABA were present in largely separate neuronal populations. Generally, GLY-IR amacrine cells were smaller, more distally located in the inner nuclear layer and had finer dendrites than GABA-IR amacrine cells. Distribution of GLY-IR and GABA-IR in the outer plexiform layer and the inner plexiform layer differed considerably.Based on the segregated distribution of GLY-IR and GABA-IR in the synaptic layers of the lizard retina, GLY and GABA may have fundamentally different roles in retinal processing.