Iodine-Catalyzed Oxidation of N-Substituted Indoles by using Chloramine-B: A Facile and Practical Approach to Isatins
Iodine-Catalyzed Oxidation of N-Substituted Indoles by using Chloramine-B: A Facile and Practical Approach to Isatins
复制标题
使用氯胺-B 碘催化 N-取代吲哚的氧化：一种简便实用的靛红制备方法
DOI：
10.1002/ejoc.201600061
复制
发表时间：
2016-04-01
影响因子：
2.8
通讯作者：
Sun, Pinghua
中科院分区：
文献类型：
--
作者：
Liu, Peijun;Guo, Jiajing;Sun, Pinghua
研究了碘催化氯胺-B氧化N-取代吲哚的反应。发现该反应耐受多种官能团，并以中等至优异的产率提供相应的靛红。此外，还实现了该方法在3-羟基吲哚和N-甲基靛红肟的一锅合成中的应用。
An efficient method for the iodine-catalyzed oxidation of N-substituted indoles by using chloramine-B under mild reaction conditions was explored. This reaction was found to be tolerant to a variety of functional groups and provided the corresponding isatins in moderate to excellent yields. In addition, application of this method to the one-pot synthesis of 3-hydroxyoxindole and N-methylisatin oxime was realized.