Host mouse strain is not selective for a laboratory adapted strain of Schistosoma mansoni.
Host mouse strain is not selective for a laboratory adapted strain of Schistosoma mansoni.
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DOI：
10.1645/ge-2671.1
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发表时间：
2011-06
期刊：
影响因子：
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通讯作者：
Blanton RE
中科院分区：
文献类型：
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作者：
Blank WA;Liu SF;Prasad J;Blanton RE
我们对来自受感染的 CF1、C57BL/6、BALB/c 和 BALB/c 干扰素 γ 敲除小鼠的曼氏血吸虫成虫进行了基因分型，以研究寄生虫基因型是否存在小鼠品系差异。我们还比较了从肝脏和肠道收集的卵的分化，以确定脊椎动物宿主中是否存在可能解释任何基因型选择的寄生虫菌株的差异分布。我们发现具有不同免疫反应的小鼠品系对感染的抵抗力没有差异，并且不会选择寄生虫基因型。曼氏沙门氏菌基因型在组织中分布均匀，成虫和卵等位基因频率没有差异。这些小鼠品系中不同的免疫反应不会显着影响宿主对血吸虫的抵抗程度或性质。
We genotyped pooled adult worms of Schistosoma mansoni from infected CF1, C57BL/6, BALB/c, and BALB/c interferon gamma knockout mice in order to investigate if mouse strain differences selected for parasite genotypes. We also compared differentiation in eggs collected from liver and intestines to determine if there was differential distribution of parasite strains in the vertebrate host that might account for any genotype selection. We found that mouse strains with differing immune responses did not differ in resistance to infection and did not select for parasite genotypes. S. mansoni genotypes were also equally distributed in tissues and there was no difference between adult and egg allele frequencies. Differing immune responses in these mouse strains does not significantly affect the degree or the nature of host resistance to schistosomes.