Experiments on an ascites hepatoma. III. The conversion of mouse hepatomas into the ascites form.
Experiments on an ascites hepatoma. III. The conversion of mouse hepatomas into the ascites form.
复制标题
腹水肝癌实验。
DOI：
10.1093/jnci/17.1.1
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发表时间：
1956
期刊：
影响因子：
--
通讯作者：
E. Essner
中科院分区：
文献类型：
--
作者：
H. Sato;M. Belkin;E. Essner
结果实体型肝癌向腹水型转化的系列实验结果如表1所示。A组的134个和129个肝癌在第一次腹膜移植中转化为岛状腹水瘤。肝癌129(P)和129(F)均为无细胞腹水型肝癌，是由肝癌129形成的岛状腹水瘤衍生而来的两个亚系。在其他5例肝癌(B组)中，腹腔接种没有导致腹水肿瘤的生长，只是产生了实体瘤组织和一定量的腹水。在某些情况下，这种腹水含有少量的肿瘤岛，但是，虽然进一步的腹膜内移植(2-4代)继续刺激接种的小鼠形成渗出物，但这并没有导致腹水肿瘤的形成。其他7例肝癌(C组)，肿瘤仅在腹膜内实体生长，未能转化为腹水瘤。两种肿瘤
ResultsThe results of the presentseries of experiments on the conversion of solid hepatomas into the ascitic form are shown in table 1. Hepatomas 134 and 129 (in group A) were converted into island ascites tumors in the first intraperitoneal transplantation. Hepatomas 129 (P) and 129 (F), which are free-cell ascites hepatomas, are two sublines derived from hepatoma 129 after its establishment as an island ascites tumor. In five other hepatomas (group B) intraperitoneal inoculation resulted not in ascites-tumor growth but only in the production of solid-tumor tissue together with a quantity of ascitic fluid. In some cases this ascitic fluid contained a small number of tumor islands but, while further intraperitoneal transplantation (2 to 4 generations) continued to stimulate exudate formation in the inoculated mice, this did not result id the formation of ascites tumors. In seven other hepatomas (group C), the tumors grew intraperitoneallyonly in solid form and failed to convert into ascites tumors. Two tumors of