Cholinergic mechanisms in startle and prepulse inhibition: effects of the false cholinergic precursor N-aminodeanol.
Cholinergic mechanisms in startle and prepulse inhibition: effects of the false cholinergic precursor N-aminodeanol.
复制标题
惊吓和前脉冲抑制中的胆碱能机制：假胆碱能前体 N-氨基脱醇的作用。
DOI：
10.1037//0735-7044.107.2.306
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发表时间：
1993
影响因子：
1.9
通讯作者：
Siegel,JM
中科院分区：
文献类型：
--
作者：
Wu,MF;Jenden,DJ;Fairchild,MD;Siegel,JM
我们研究了胆碱能缺乏对声惊吓前脉冲抑制（PPI）的影响。用含有假胆碱能前体N-氨基乙醇的无胆碱饮食治疗的大鼠显示PPI严重不足。这一缺陷似乎并不继发于陈规定型行为的增加。惊吓阈值也大大降低，因为这些大鼠对70 dB前脉冲惊吓，并且基线惊吓幅度比对照大鼠增加60%。槟榔碱（4 mg/kg）部分逆转了PPI的不足。这种改善持续超过药物治疗期。另一方面，东莨菪碱（1 mg/kg）降低PPI在对照组大鼠。这些结果表明，胆碱能系统在惊吓的诱发和前脉冲抑制中起着重要作用。
We examined the effects of cholinergic deficiency on prepulse inhibition (PPI) of the acoustic startle. Rats treated with a choline-free diet that contained the false cholinergic precursor N-aminodeanol showed great deficit in PPI. This deficit does not appear to be secondary to an increase of stereotyped behaviors. Startle threshold was also greatly reduced, as these rats startled to the 70-dB prepulse and the baseline startle amplitude was increased by 60% over the control rats. Arecoline (4 mg/kg) partially reversed the deficit in PPI. This improvement persisted beyond the period of drug treatment. On the other hand, scopolamine (1 mg/kg) reduced PPI in the control rats. These results suggest that cholinergic systems play a major role in both the elicitation and prepulse inhibition of startle.