Erythrocyte count is associated with prognosis in Chinese patients with primary biliary cholangitis
Erythrocyte count is associated with prognosis in Chinese patients with primary biliary cholangitis
复制标题
红细胞计数与中国原发性胆汁性胆管炎患者的预后相关
DOI：
10.3892/etm.2020.8446
复制
发表时间：
2020-03-01
影响因子：
2.7
通讯作者：
Han, Ying
中科院分区：
文献类型：
--
作者：
Chang, Yinghao;Guo, Changcun;Han, Ying
红细胞参数已被表明是肝脏疾病的重要预后因素。本研究旨在评价红细胞计数在中国原发性胆汁性胆管炎（PBC）患者中的预后价值，并建立一个预后模型。回顾性分析301例PBC患者的临床资料。单因素和多因素考克斯回归分析，以确定潜在的预后危险因素。采用双变量相关分析确定红细胞计数与生化指标的相关系数。采用受试者工作特征（ROC）曲线分析比较不同因素对预后的影响。采用多变量logistic回归建立了一个新的预后模型。多因素回归分析显示红细胞计数是独立的危险因素/预后指标（P=0.042）。外周血红细胞计数随组织学分期的进展而降低（P<0.001）。红细胞计数与白蛋白、肝硬度和纤维化-4相关。红细胞计数的ROC曲线下面积明显大于血小板计数。红细胞计数、白蛋白和总胆红素的ROC曲线下面积相似（P>0.05）。建立了一个新的预后模型：P=1/{1 + e-[6.140-3.193 × Ln（红细胞计数）-0.184 ×白蛋白+0.827 × Ln（总胆红素）]}。新模型的预后价值与地球仪评分和UK-PBC风险评分相当，并且在基线时的性能优于马约风险评分（0.838 vs. 0.787）。总之，红细胞计数是中国PBC患者的独立危险因素/预后指标。在中国患者中，它与肝功能和纤维化相关。结合基线红细胞计数和生化指标的新模型可作为中国PBC患者的预后工具（试验注册号，ChiCTR-ONRC-10002070;注册日期，2010年5月10日）。
Erythroid parameters have been indicated to be important prognostic factors for liver diseases. The present study aimed to evaluate the prognostic value of the erythrocyte count in Chinese patients with primary biliary cholangitis (PBC) and develop a prognostic model. The clinical data of 301 patients with PBC were retrospectively reviewed. Univariate and multivariate Cox regression analysis was performed to identify potential prognostic risk factors. Bivariate correlation analysis was used to determine the correlation coefficient of the erythrocyte count and biochemical indices. The prognostic values of different factors were compared by receiver operating characteristic (ROC) curve analysis. A novel prognostic model was constructed using multivariate logistic regression. Multivariate regression analysis suggested that the erythrocyte count was an independent risk factor/prognostic index (P=0.042). The erythrocyte count in peripheral blood decreased as the histological stage progressed (P<0.001). The erythrocyte count was correlated with albumin, liver stiffness and Fibrosis-4. Compared with that of platelets, the area under the ROC curve of the erythrocyte count was significantly greater. A similar area under the ROC curve was determined for the erythrocyte count, albumin and total bilirubin (P>0.05). A novel prognostic model was established as follows: P=1/{1 + e-[6.140–3.193 × Ln(erythrocyte count) −0.184 × albumin + 0.827 × Ln(total bilirubin)]}. The novel model had a comparable prognostic value to that of the GLOBE score and UK-PBC risk score, and had a better performance than the Mayo risk score at baseline (0.838 vs. 0.787). In conclusion, the erythrocyte count is an independent risk factor/prognostic index in Chinese patients with PBC. It was correlated with liver function and fibrosis in Chinese patients. The novel model incorporating the erythrocyte count and biochemical indices at baseline may serve as a prognostic tool in Chinese patients with PBC (Trial registration number, ChiCTR-ONRC-10002070; date of registration, 2010-05-10).