THE SPATIAL PATTERNS OF PLAQUES AND TANGLES IN ALZHEIMERS-DISEASE DO NOT SUPPORT THE CASCADE HYPOTHESIS
THE SPATIAL PATTERNS OF PLAQUES AND TANGLES IN ALZHEIMERS-DISEASE DO NOT SUPPORT THE CASCADE HYPOTHESIS
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DOI：
10.1159/000107291
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发表时间：
1993-01-01
期刊：
影响因子：
--
通讯作者：
SMITH, CUM
中科院分区：
文献类型：
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作者：
ARMSTRONG, RA;MYERS, D;SMITH, CUM
In Alzheimer's disease (AD), the 'Cascade hypothesis' proposes that the formation of paired helical filaments (PHF) may be causally linked to the deposition of beta/A4 protein. Hence, there should be a close spatial relationship between senile plaques and cellular neurofibrillary tangles in a local region of the brain. In tissue from 6 AD patients, plaques and tangles occurred in clusters and individual clusters were often regularly spaced along the cortical strip. However, the clusters of plaques and tangles were in phase in only 4/32 cortical tissues examined. Hence, the data were not consistent with the 'Cascade hypothesis' that beta/A4 and PHF are directly linked in AD.
