VARIATIONS IN THE INTRINSIC MECHANICAL PROTERTIES OF HUMAN ARTICULAR-CARTILAGE WITH AGE, DEGENERATION, AND WATER-CONTENT
VARIATIONS IN THE INTRINSIC MECHANICAL PROTERTIES OF HUMAN ARTICULAR-CARTILAGE WITH AGE, DEGENERATION, AND WATER-CONTENT
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DOI：
10.2106/00004623-198264010-00013
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发表时间：
1982-01-01
影响因子：
5.3
通讯作者：
MOW, VC
中科院分区：
文献类型：
--
作者：
ARMSTRONG, CG;MOW, VC
采用有限压缩蠕变试验，对103个人膝关节外侧小关节标本进行了关节软骨的本征力学性能测试。通过将软骨视为充满流体的多孔、可渗透固体，该实验方法允许确定软骨基质的内在平衡模数及其对流体流动的渗透性。组织的本征平衡模数和渗透率与组织的含水率高度相关；随着含水率的增加，组织的基质变得更柔软和更具渗透性。随着年龄的增加和表面的退变，组织的平衡模数仅略有下降。软骨基质的通透性与年龄或退变无明显相关性。软骨标本的视觉或组织学外观可能不能很好地表明其作为完整关节的承重材料的能力。通过直接机械测试或通过对其成分进行生化分析，可以获得更可靠的样品功能特性指示器。
In 103 specimens from the lateral facet of the human patella, the intrinsic mechanical properties of articular cartilage were measured using a confined compression creep test. By considering the cartilage as a porous, permeable solid filled with fluid, this experimental procedure allowed the determination of the intrinsic equilibrium modulus of the cartilage matrix and its permeability to fluid flow. The intrinsic equilibrium modulus and the permeability were highly correlated with the water content of the tissue; as water content increased, the matrix of the tissue became softer and more permeable. There was only a marginal decrease in the equilibrium modulus of the tissue with increasing age and surface degeneration. The permeability of the cartilage matrix was not significantly correlated with age or degeneration. Visual or histological appearance of a cartilage specimen may be a poor indicator of its ability to function as the bearing material in the intact joint. A more reliable indicator of the functional properties of a specimen can be obtained by direct mechanical testing or by biochemical analysis of its composition.