Catheter-tip colonization as a surrogate end point in clinical studies on catheter-related bloodstream infection: How strong is the evidence?
Catheter-tip colonization as a surrogate end point in clinical studies on catheter-related bloodstream infection: How strong is the evidence?
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DOI：
10.1086/342905
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发表时间：
2002-11-01
影响因子：
11.8
通讯作者：
Peetermans, WE
中科院分区：
文献类型：
--
作者：
Rijnders, BJA;Van Wijngaerden, E;Peetermans, WE
在临床试验中，导管尖端定植（CTC）的发生率经常被用作导管相关血流感染（BSI）发生率的替代终点。目前尚不清楚CTC和导管相关BSI之间的相关性是否良好。我们检索了MEDLINE数据库，并进行了1990-2002年的文献检索，检索到29项研究（共60个研究组），其发生率数据与预定义的CTC和导管相关BSI定义有关。CTC与导管相关BSI之间存在良好的线性相关性（r = 0.69; r（2）= 0.48; P <0.001）。关于导管相关感染的医学文献数据似乎支持使用CTC作为导管相关BSI的替代终点。在评价预防导管相关BSI的临床干预措施或新技术时，研究CTC的预防似乎是合乎逻辑的第一步。
In clinical trials, the incidence of catheter-tip colonization (CTC) is frequently used as a surrogate end point for the incidence of catheter-related bloodstream infection (BSI). It is not clear whether the correlation between CTC and catheter-related BSI is good. We searched the MEDLINE database and conducted a literature search for the years 1990-2002 and retrieved 29 studies (with a total of 60 study groups) with incidence data on predefined CTC and catheter-related BSI definitions. A good linear correlation between CTC and catheter-related BSI was found (r = 0.69; r(2) = 0.48; P < .001). The data from the medical literature about catheter-related infection seem to support the use of CTC as a surrogate end point for catheter-related BSI. In evaluations of clinical interventions or new techniques for the prevention of catheter-related BSI, investigation of the prevention of CTC seems to be a logical first step.